Results 241 to 250 of about 2,669,618 (392)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Adverse pregnancy outcomes and associated factors among mothers who had operative vaginal delivery in Amhara Region Comprehensive Specialized Hospitals: multicentre cross-sectional study. [PDF]

BMJ Open
Misker AD, Melesew AA, Gobezie NZ, Wubet HB, Diress GM, Abuhay AG, Demite DG, Tadesse MA, Mihretie GN, Abate AT, Asmare TB, Goshu YA, Siyoum TM, Mekuriaw BY, Gedefaw GD, Kebede SD, Demissie B, Afework WA.   +17 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Comparative Study of Minimally Invasive Plate Osteosynthesis Versus Open Reduction and Internal Fixation in the Treatment of Distal Fibular Fractures. [PDF]

J Orthop Case Rep
Bhuimali A, Mondal A, Dandi S, Koley A.
europepmc   +1 more source

Studies of the processes operative in solutions. XXVII.—The causes of variation in the optical rotatory power of organic compounds and of anomalous rotatory dispersive power

, 1913
HENRY E. ARMSTRONG, Emily Walker
openalex   +1 more source

Habitual Dislocation of the Patella Treated Operatively Ad Modum Goldthwait [PDF]

, 1945
Knud Stakemann Seedorff
openalex   +1 more source

Trends in hospital volume and operative mortality for high-risk surgery.

New England Journal of Medicine, 2011
Jonathan F. Finks, N. Osborne, J. Birkmeyer   +2 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Management of Stone Disease in the Spina Bifida Patient. [PDF]

Curr Urol Rep
Davis MF, Yu KL, Srinivasan AK.
europepmc   +1 more source

Co-operative Activation [PDF]

, 1939
W. E. Garner
openalex   +1 more source