Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Surgical Trainee Familiarity and Knowledge of the Commission on Cancer Operative Standards: A National Survey Study. [PDF]
Baskin AS +13 more
europepmc +1 more source
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Functional Outcomes of Total Hip Arthroplasty using Modified Harris Hip Score and Oxford Hip Score: A Prospective Study. [PDF]
Jose ML +5 more
europepmc +1 more source
Variations in post-operative cataract surgery instructions among eye health workers in Tanzania: a cross-sectional survey. [PDF]
Dhalla KA +4 more
europepmc +1 more source
The Second Look: The Future of Surgical Education. [PDF]
Safadi M, Abboud W, Farah A.
europepmc +1 more source
Patient satisfaction and scope size of flexible ureteroscopy for upper urinary stones: A comparative study, multivariate analysis and subjective and objective evaluations. [PDF]
Hekal IA, Hekal YI, Hekal JI, Memari AA.
europepmc +1 more source

