Results 171 to 180 of about 1,120,982 (307)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Operative burden and resuscitation resource utilisation in patients with traumatic shock requiring urgent surgical or endovascular intervention. [PDF]

Eur J Trauma Emerg Surg
Noonan M, O'Loan M, Hendel S, Fitzgerald M, Ban EJ, Huynh F, McKay S, Scorer A, Goh GS, Pilgrim CHC.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative Outcomes of Minimally Invasive Surgical Approaches on Patient Recovery: A Systematic Review. [PDF]

Cureus
Rathod AP, Shrivastava V, Tiwari NK, Sonune A, Thekdi PI, Sambhav K, Dange KJ.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Defining spine care: a framework for scope, standards, and bidirectional care transitions. [PDF]

J Spine Surg
Lewandrowski KU, Lorio MP, Schömig F, Pumberger M, Vaccaro AR.   +4 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Standard-Based Port-Sharing Workflow for Simultaneous Robot-Assisted Distal Gastrectomy and Right-Sided Colectomy: A Case Report. [PDF]

Surg Case Rep
Ueda S, Yamazaki S, Takahashi M, Masubuchi M, Kunitomo A, Shinohara K, Matsumura T, Fukami Y, Wakabayashi K, Sano T, Ito Y.   +10 more
europepmc   +1 more source

Optimizing cerebrovascular surgical and endovascular procedures in children via personalized 3D printing.

Journal of Neurosurgery: Pediatrics, 2015
Peter Weinstock, S. Prabhu, K. Flynn, D. Orbach, E. Smith   +4 more
semanticscholar   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source