Results 51 to 60 of about 10,463 (309)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Discrete fractional calculus with the nabla operator

Electronic Journal of Qualitative Theory of Differential Equations, 2009
Properties of discrete fractional calculus in the sense of a backward difference are introduced and developed. Exponential laws and a product rule are developed and relations to the forward fractional calculus are explored.
F. M. Atici, Paul Eloe
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Feynman calculus for random operator-valued functions and their applications

Учёные записки Казанского университета: Серия Физико-математические науки, 2018
The Feynman–Chernoff iteration of a random semigroup of bounded linear operators in the Hilbert space has been considered. The convergence of mean values of the Feynman–Chernoff iteration of a random semigroup has been studied.
V.Zh. Sakbaev, O.G. Smolyanov
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Bang Calculus and the Two Girard's Translations [PDF]

Electronic Proceedings in Theoretical Computer Science, 2019
We study the two Girard's translations of intuitionistic implication into linear logic by exploiting the bang calculus, a paradigmatic functional language with an explicit box-operator that allows both call-by-name and call-by-value lambda-calculi to be ...
Giulio Guerrieri, Giulio Manzonetto
doaj   +1 more source

Non-commutative functional calculus: Unbounded operators [PDF]

Journal of Geometry and Physics, 2009
In a recent work, \cite{cgss}, we developed a functional calculus for bounded operators defined on quaternionic Banach spaces. In this paper we show how the results from \cite{cgss} can be extended to the unbounded case, and we highlight the crucial differences between the two cases.
Sabadini, Irene, Colombo, Fabrizio, Struppa, Daniele, Sabadini, Irene, Gentili, Graziano, Colombo, Fabrizio, Struppa, D., Struppa, Daniele, Gentili, Graziano, Sabadini, I., Gentili, G., Colombo, F.   +11 more
openaire   +8 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

The Heaviside Operational Calculus [PDF]

Bell System Technical Journal, 1922
The art of electrical communication owes a great and increasingly recognized debt to Oliver Heaviside for his work in developing and emphasizing a correct theory of electrical transmission along wires and in particular for his insistance on the importance of inductance. His operational methods of solving the differential equations which are fundamental
openaire   +3 more sources