Results 91 to 100 of about 521,948 (283)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Compact Weighted Composition Operators and Multiplication Operators between Hardy Spaces

Abstract and Applied Analysis, 2008
We estimate the essential norm of a compact weighted composition operator 𝑢𝐶𝜑 acting between different Hardy spaces of the unit ball in ℂ𝑁. Also we will discuss a compact multiplication operator between Hardy spaces.
Sei-Ichiro Ueki, Luo Luo
doaj   +1 more source

Succinctness in subsystems of the spatial mu-calculus

, 2017
In this paper we systematically explore questions of succinctness in modal logics employed in spatial reasoning. We show that the closure operator, despite being less expressive, is exponentially more succinct than the limit-point operator, and that the $
Fernández-Duque, David, Iliev, Petar
core  

Interpolation of Operator Spaces

Journal of Functional Analysis, 1996
The author develops a theory of real interpolation for operator spaces. The theory presented is a counterpart to \textit{G. Pisier's} recent work on a complex interpolation theory for operator spaces [``The operator Hilbert space OH, complex interpolation and tensor norms'', Mem. Am. Math. Soc. 585, 103 p. (1996)].
openaire   +2 more sources

Quasi-multipliers of operator spaces

Journal of Functional Analysis, 2004
We use the injective envelope to study quasimultipliers of operator spaces. We prove that all representable operator algebra products that an operator space can be endowed with are induced by quasimultipliers. We obtain generalizations of the Banach-Stone theorem.
Kaneda, Masayoshi, I. Paulsen, Vern
openaire   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

On the small scale nonlinear theory of operator spaces

Comptes Rendus. Mathématique
We initiate the study of the small scale geometry of operator spaces. The authors have previously shown that a map between operator spaces which is completely coarse (that is, the sequence of its amplifications is equi-coarse) must be $\mathbb{R}$-linear.
Braga, Bruno M., Chávez-Domínguez, Javier Alejandro   +1 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source