Results 61 to 70 of about 521,948 (283)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Sharp Bounds for Fractional Conjugate Hardy Operator on Higher-Dimensional Product Spaces
Journal of Function Spaces, 2020 In this paper, we obtain the sharp bound for fractional conjugate Hardy operator on higher-dimensional product spaces from L1ℝn1×⋯×ℝnm to the space wLQℝn1×⋯×ℝnm and Lpℝn1×⋯×ℝnm to the space Lqℝn1×⋯×ℝnm. More generally, the operator norm of the fractional
Zequn Wang +3 more
doaj +1 more source
Operator valued Hardy spaces [PDF]
Memoirs of the American Mathematical Society, 2007 We give a systematic study on the Hardy spaces of functions with values in the non-commutative $L^p$-spaces associated with a semifinite von Neumann algebra ${\cal}M.$ This is motivated by the works on matrix valued Harmonic Analysis (operator weighted norm inequalities, operator Hilbert transform), and on the other hand, by the recent development on ...
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Strict singularity of a Volterra-type integral operator on $H^p$ [PDF]
, 2015 We prove that a Volterra-type integral operator $T_gf(z) = \int_0^z f(\zeta)g'(\zeta)d\zeta, \, z \in \mathbb D,$ defined on Hardy spaces $H^p, \, 1 \le p < \infty,$ fixes an isomorphic copy of $\ell^p,$ if the operator $T_g$ is not compact.
Miihkinen, Santeri
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
, 2012 If $g$ is an analytic function in the unit disc $\D $ we consider the generalized Hilbert operator $\hg$ defined by {equation*}\label{H-g} \mathcal{H}_g(f)(z)=\int_0^1f(t)g'(tz)\,dt.
Galanopoulos, Petros +3 more
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The Method of almost convergence with operator of the form fractional order and applications
, 2016 The purpose of this paper is twofold. First, basic concepts such as Gamma function, almost convergence, fractional order difference operator and sequence spaces are given as a survey character.
Kadak, Ugur, Kirisci, Murat
core +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source