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Operon identifier: Identification of operon structures in the whole genome
Proceedings II of the 28st Conference STUDENT EEICT 2022: Selected papers., 2022Currently, operon prediction is based on the distance of neighboring genes on the functional relationships of their products that encode proteins in a given nucleotide sequence, or on ORF distances. This study deals with the design of a new function that detects operon structures based on information from gene expression or alternatively in combination
Nejezchlebová, Julie +1 more
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Trends in Biochemical Sciences, 1991
Ribosomal RNA (rRNA) operons of the archaea reflect both the unity and the diversity of this third primary taxon. They have proven to be a rich source of both molecular biological and phylogenetic information.
Garrett, Roger A. +4 more
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Ribosomal RNA (rRNA) operons of the archaea reflect both the unity and the diversity of this third primary taxon. They have proven to be a rich source of both molecular biological and phylogenetic information.
Garrett, Roger A. +4 more
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The Origin and Evolution of Operons: The Piecewise Building of the Proteobacterial Histidine Operon
Journal of Molecular Evolution, 2005The structure and organization of 470 histidine biosynthetic genes from 47 different proteobacteria were combined with phylogenetic inference to investigate the mechanisms responsible for assembly of the his pathway and the origin of his operons. Data obtained in this work showed that a wide variety of different organization strategies of his gene ...
FANI, RENATO, M. Brilli, P. Liò
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Polarity in the histidine operon
Journal of Molecular Biology, 1966Abstract Sixty-eight mutants in the C gene of the histidine operon in Salmonella typhimurium have been examined for polarity. All nonsense and frameshift mutants were found to be polar, whereas none of the missense mutants exhibited polarity. The mutants mapping on the side of the C cistron towards the operator region were more strongly polar ...
R G, Martin +3 more
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The Structure of the mer Operon
1985The DNA sequence has been determined for a 3.8-kb region which encodes the mercury-resistance (mer) operon of the IncFII plasmid NR1. The sequence reveals 4 open reading frames which could encode proteins of 12,522, 9,429, 14,965, and 58,912 d corresponding to the 4 previously described Hg-inducible proteins detected in minicells carrying mer+ plasmids.
P, Barrineau +5 more
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Regulation of the lactose operon in vitro
Molecular and General Genetics MGG, 1970Using DNA of phage ϕ80p lac carrying lac-operon (i+o+z+y+), the transcription of the lac-operon was studied in vitro. The lac-specific mRNA having a molecular size of 28S was detected by hybridizing messenger RNA (mRNA) from induced cells (diploid for the lac-operon) to the ϕ80p lac DNA. The hybridization of lac-specific mRNA to ϕ80p lac DNA was almost
Y, Iida +3 more
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microRNAs and the Operon Paper
Journal of Molecular Biology, 2011The "Operon paper" by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs (miRNAs) emerged as major regulators of eukaryotic gene expression. Here, I will review the basic principles of gene regulation by miRNAs and how these principles can be ...
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Operon prediction by Markov clustering
International Journal of Data Mining and Bioinformatics, 2014The prediction of operons is a critical step for the reconstruction of biochemical and regulatory networks at the whole genome level. In this paper, a novel operon prediction model is proposed based on Markov Clustering (MCL). The model employs a graph-clustering method by MCL for prediction and does not need a classifier.
W. Du +5 more
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The Post-transcriptional Operon
2010A post-transcriptional operon is a set of monocistronic mRNAs encoding functionally related proteins that are co-regulated by a group of RNA-binding proteins and/or small non-coding RNAs so that protein expression is coordinated at the post-transcriptional level. The post-transcriptional operon model (PTO) is used to describe data from an assortment of
Tenenbaum, Scott A. +2 more
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Journal of Molecular Biology, 2013
The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
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The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
openaire +2 more sources