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microRNAs and the Operon Paper
Journal of Molecular Biology, 2011The "Operon paper" by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs (miRNAs) emerged as major regulators of eukaryotic gene expression. Here, I will review the basic principles of gene regulation by miRNAs and how these principles can be ...
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Operon prediction by Markov clustering
International Journal of Data Mining and Bioinformatics, 2014The prediction of operons is a critical step for the reconstruction of biochemical and regulatory networks at the whole genome level. In this paper, a novel operon prediction model is proposed based on Markov Clustering (MCL). The model employs a graph-clustering method by MCL for prediction and does not need a classifier.
W. Du +5 more
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The Post-transcriptional Operon
2010A post-transcriptional operon is a set of monocistronic mRNAs encoding functionally related proteins that are co-regulated by a group of RNA-binding proteins and/or small non-coding RNAs so that protein expression is coordinated at the post-transcriptional level. The post-transcriptional operon model (PTO) is used to describe data from an assortment of
Tenenbaum, Scott A. +2 more
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Journal of Molecular Biology, 2013
The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
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The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
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2021
The lac operon regulatory mechanism allows bacteria to sense external nutrient conditions and, accordingly, regulate gene transcription that assists in the digestion of available nutrients. The lac system produces a switch-like dynamic behavior, where the switching between ‘on’ and ‘off’ states of lac gene transcription depends on the specific ...
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The lac operon regulatory mechanism allows bacteria to sense external nutrient conditions and, accordingly, regulate gene transcription that assists in the digestion of available nutrients. The lac system produces a switch-like dynamic behavior, where the switching between ‘on’ and ‘off’ states of lac gene transcription depends on the specific ...
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Improved BioCyc Operon Prediction: Revisiting the Operon Prediction Problem
Abstract Introduction Operon prediction is a valuable component of microbial-genome annotation because operon organization can yield inferences about gene function, and because knowledge of operon structure can aid the interpretation of gene expression data.Peter E. Midford +2 more
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Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond
Annual Review of Biochemistry, 2021Max A English +2 more
exaly
COMPUTATIONAL ELUCIDATION OF OPERONS AND UBER-OPERONS
2008PHUONGAN DAM +6 more
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2000
Abstract The culmination of the work on gene action and its regulation occurred in 1961 with the formulation of the Operon Model by Jacob and Monod. This combined all the steps of protein synthesis, so carefully assembled since 1953, with the regulatory mechanisms described in Chapters 12 and 13, in a complete picture.
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Abstract The culmination of the work on gene action and its regulation occurred in 1961 with the formulation of the Operon Model by Jacob and Monod. This combined all the steps of protein synthesis, so carefully assembled since 1953, with the regulatory mechanisms described in Chapters 12 and 13, in a complete picture.
openaire +1 more source