Results 171 to 180 of about 6,924,662 (223)

Quantitative Determination of Pilocarpine in Ophthalmic Solutions

Journal of Pharmaceutical Sciences, 1965
A method is described for the quantitative determination of pilocarpine in ophthalmic solutions. It is based on reaction with hydroxylamine in an alkaline medium to give the hydroxamic acid, which is complexed with ferric ion. Although the color produced is relatively unstable, the method has a high degree of precision if the experimental conditions ...
Joseph D. Benmaman, E. Brochmann-Hanssen, P. Schmid   +2 more
openaire   +3 more sources

PREPARATION AND MAINTENANCE OF STERILE OPHTHALMIC SOLUTIONS

Journal of the American Medical Association, 1953
Serious ocular infections resulting from the use of contaminated ophthalmic solutions are becoming increasingly prevalent. This situation may be directly attributed to the astounding fact that in the United States, until recently,1no section of the Federal Food, Drug, and Cosmetic Act was interpreted as requiring manufacturers and dispensers of eye ...
Robert R. Feinstein, Frederick H. Theodore   +1 more
openaire   +3 more sources

The Clinical Significance of the pH of Ophthalmic Solutions*,†

Journal of the American Pharmaceutical Association (Scientific ed.), 1953
Abstract The clinical significance of the p H of ophthalmic solutions was determined by intrasubject comparison of the pharmacologic effects of drug solutions differing only with regard to their p H. For pilocarpine and ephedrine the conclusion was reached that the clinical significance of the p H of the vehicle was small unless the vehicle was ...
Peter C. Kronfeld, Glen Floyd, James E. McDonald   +2 more
openaire   +3 more sources

Cytotoxicity of ophthalmic solutions with and without preservatives to human corneal endothelial cells, epithelial cells and conjunctival epithelial cells

Clinical and Experimental Ophthalmology, 2008
Purpose:  The cytotoxicity of a range of commercial ophthalmic solutions in the presence and absence of preservatives was assessed in human corneal endothelial cells (HCECs), corneal epithelia and conjunctival epithelia using in vitro techniques.
M. Ayaki, S. Yaguchi, A. Iwasawa, R. Koide   +3 more
semanticscholar   +1 more source

Measurement of AQCmax of five different ophthalmic solutions and discussion of its new application.

Journal of Ocular Pharmacology and Therapeutics, 2009
PURPOSE After measuring the pharmacokinetic parameters of five fluoroquinolone ophthalmic solutions, we utilized the obtained indices to try to predict the clinical effects of antimicrobial ophthalmic solutions and apply the characteristics to the index ...
M. Fukuda, H. Sasaki
semanticscholar   +1 more source

An Evaluation of Chemical Preservatives for Ophthalmic Solutions*

Journal of the American Pharmaceutical Association (Scientific ed.), 1955
Data are presented on the relative antimicrobial activities of seven commonly used chemical compounds that are used for preserving ophthalmic drug solutions from Pseudomonas and Proteus contaminations. In testing the compounds against 26 strains of Pseudomonas aeruginosa and four species of Proteus in a simple buffer solution, in the absence of an ...
openaire   +3 more sources

Absorption of Brimonidine 0.1% and 0.15% Ophthalmic Solutions in the Aqueous Humor of Cataract Patients

Journal of glaucoma, 2008
PurposeTo determine and compare the human aqueous humor (AH) concentrations of 2 formulations of brimonidine ophthalmic solution [0.1% brimonidine Purite (BP) (average pH 7.4 to 8.0) and 0.15% BP (average pH 6.6 to 7.4)].
L. Cantor, D. WuDunn, Y. Catoira-Boyle, C. Yung   +3 more
semanticscholar   +1 more source

THE pH AND TONICITY OF OPHTHALMIC SOLUTIONS

Archives of Ophthalmology, 1943
The hydrogen ion concentration of the solution in which an ophthalmic drug is dissolved may alter the therapeutic results of the drug itself. A variation of thepHoften determines the speed and the quantity of absorption of the drug and the amount of irritation which the patient experiences on instillation.
openaire   +2 more sources

METHYL CELLULOSE SOLUTION FOR OPHTHALMIC USE

Archives of Ophthalmology, 1951
THE USE of methyl cellulose solutions in ophthalmology is growing daily.1Because there is a variation in the concentrations recommended for use, as reported in the literature, my associates and I have tried to determine the concentration of methyl cellulose which would be most satisfactory and the proper composition of solutions of this substance.
openaire   +3 more sources

Antibacterial agents in Pseudomonas aeruginosa contaminated ophthalmic solutions.

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1956
The criteria of sterility of ophthalmic solutions has been based on in vitro bacterio-logical studies. In vivo rabbit corneal tests along with improved techniques of invitro testing indicate that bactericidal concentrations of preservatives are ...
S. Riegelman, D. Vaughan, M. Okumoto
semanticscholar   +1 more source