Results 51 to 60 of about 8,860 (245)

Characteristics and surgical outcomes of pediatric traumatic macular holes

BMC Ophthalmology
Background Due to the small number of cases, limited knowledge exists on the surgical outcome of pediatric traumatic macular holes (MHs). This study aims to investigate the characteristics and surgical outcomes of pediatric traumatic MHs and analyse the ...
Ying Cui, Ge Wang, Xiangyu Shi
doaj   +1 more source

Modulação da cicatrização na cirurgia do glaucoma após aplicação de acetato de triancinolona subconjuntival isolado ou em associação à mitomicina C: estudo experimental

Revista do Colégio Brasileiro de Cirurgiões, 2018
RESUMO Objetivo: estudar a eficácia e segurança do uso de acetato de triancinolona subconjuntival isolado ou em associação à mitomicina C como modulador da cicatrização de trabeculectomias em coelhos.
Hayana Marques do Aragão Rangel, Hévila Tamar Rolim, Paula Vidigal, Ivana Duval de Araújo, Sebastião Cronemberger   +4 more
doaj   +1 more source

Spatially Confined/Ligand‐Directed Ultrabright NIR‐AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis

Advanced Science, EarlyView.
Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li, Jia Shu, Sijia Lv, Leilei Qin, Xuefeng Luo, PengCheng Xiao, Huan Cai, Xin Gao, Yan Zhao, Haotian Zhou, Yaji Yang, Zhenglin Zhu, Shijia Ding, Juan Li, Rui Chen, Wei Huang   +15 more
wiley   +1 more source

Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Angewandte Chemie, EarlyView.
Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan, Shang Zhu, Hang Song, Fei Wang, Zikai He, Sijie Chen, Engui Zhao   +6 more
wiley   +2 more sources

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Intraoperative optical coherence tomography in ophthalmology: Technologies and applications

Taiwan Journal of Ophthalmology
Intraoperative optical coherence tomography (iOCT) offers valuable real-time, depth-resolved visualization of ocular anatomy and during ophthalmic surgical maneuvers, which can be used to augment clinical decision-making, help verify surgical endpoints ...
Yuankai K. Tao
doaj   +1 more source

Effects of the Covid-19 pandemic on eye care for patients in a referral training hospital [PDF]

Revista Brasileira de Oftalmologia
Objective: To assess the impact of the Covid-19 pandemic on the number of medical appointments, exams and procedures performed in a public ophthalmic teaching hospital in Brazil.
Camila Ribeiro Koch, Camila Coli Mendes Lima, Eloah Nunes Torres, Gentil Aurélio Silva Luz Júnior, Leonardo Oliveira Novaes, Renata Fernandes Cunha, Milton Ruiz Alves   +6 more
doaj   +1 more source

Dual Suppression of Oxidative Stress and JAK/STAT3 Signaling Attenuates Inflammation‐Driven Corneal Neovascularization

Advanced Science, EarlyView.
Corneal neovascularization is sustained by oxidative stress and inflammatory STAT3 signaling. A macrophage membrane‐cloaked nanozyme, Sta@MSR, combines ruthenium‐mediated ROS scavenging with Stattic‐mediated STAT3 inhibition. Delivered as eye drops, Sta@MSR enhances ocular retention and corneal penetration, reduces inflammatory and angiogenic responses,
Qinghua Li, Ruoxi Li, Bingxin Ren, Chaoya Gong, Hui Yan, Jie Chen, Benzhao Fu, Chaoqun Wei, Qingdong Bao, Yang Li, Xiaoxue Liu, Wenlong Li, Hua Gao   +12 more
wiley   +1 more source

A Bioengineered Mitochondrial Respiration‐Mimetic Copper‐Based Metal‐Organic Framework Reprogramming Oxidative Phosphorylation to Enhance Tumor Cuproptosis

Advanced Science, EarlyView.
A bioengineered mitochondrial respiration‐mimetic nanoplatform (TC@OMG) renews tumor mitochondrial metabolism to enhance cuproptosis. TC@OMG integrates a copper‐based metal‐organic framework co‐loaded with glucose oxidase and a lactate dehydrogenase inhibitor, and is cloaked with a hybrid membrane derived from tumor cells and plant thylakoids, enabling
Liyang Zhou, Hongpei Deng, Tingli Zheng, Huan Min, Qiwei Tian, Huimin Lin, Jing Ruan, Xianqun Fan   +7 more
wiley   +1 more source