Results 171 to 180 of about 206,292 (355)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Albinism: management and care of ophthalmological manifestations [PDF]

International audienceAlbinism is a heterogeneous disorder characterized by both dermatological and ophthalmological expressions. In ophthalmological practice, patients with albinism frequently present with nystagmus and reduced visual acuity, the ...
Robert, Matthieu, Bremond-Gignac, Dominique, Rateaux, Maxence   +2 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Investigation of Differences in the Techniques of Experimental Vitreo-retinal Operations on Laboratory Animals

Oftalʹmologiâ
The continuous development of vitreoretinal surgery makes it possible to provide high-tech care to patients with retinal detachment while minimizing intraand postoperative complications. However, their percentage still remains significantly high.
I. B. Alekseev, V. E. Belkin, O. I. Abramova   +2 more
doaj   +1 more source

Correlation between weather and incidence of selected ophthalmological diagnoses: a database analysis [PDF]

, 2016
Christoph Kern, Karsten Kortüm, Michael Müller, Florian Raabe, Wolfgang Johann Mayer, Siegfried Priglinger, Thomas Christian Kreutzer University Eye Hospital Munich, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich,
Müller M, Raabe F, Mayer WJ, Priglinger S, Kreutzer TC, Kern C, Kortüm K   +6 more
core  

Early ophthalmological tumour signs and diagnostic interval in children with brain tumours [PDF]

BackgroundChildren with brain tumours often suffer from late diagnosis, impacting cure rates and risk of permanent sequelae. Ophthalmological symptoms are common, and we aimed to investigate the frequency, diagnostic interval, and prognostic value of ...
von Holstein, Sarah Linea, Heegaard, Steffen, Siersma, Volkert, Kjeldsen, Sia, Schmiegelow, Kjeld, Mathiasen, René, Christiansen, Jacob   +6 more
core   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Comparação entre acuidade visual e photoscreening como métodos de triagem visual para crianças em idade escolar Comparison between visual acuity and photoscreening used like visual screening methods for scholar aged children

Revista Brasileira de Oftalmologia, 2012
OBJETIVO: Avaliar a sensibilidade do aparelho photoscreener na detecção de alterações oculares em crianças informantes, comparando os dados à acuidade visual obtida pela tabela E de Snellen.
Roberta Lílian Fernandes de Sousa, Bruno Schiavoni Funayama, Luciana Catâneo, Carlos Roberto Padovani, Silvana Artioli Schellini   +4 more
doaj