Results 101 to 110 of about 682,776 (395)

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Validating Variational Bayes Linear Regression Method With Multi-Central Datasets. [PDF]

, 2018
PurposeTo validate the prediction accuracy of variational Bayes linear regression (VBLR) with two datasets external to the training dataset.MethodThe training dataset consisted of 7268 eyes of 4278 subjects from the University of Tokyo Hospital.
Asaoka, Ryo, Fujino, Yuri, Hirasawa, Kazunori, Kashiwagi, Kenji, Matsuura, Masato, Miki, Atsuya, Mizoue, Shiro, Mori, Kazuhiko, Murata, Hiroshi, Shoji, Nobuyuki, Suzuki, Katsuyoshi, Tanito, Masaki, Yamashita, Takehiro, Zangwill, Linda M   +13 more
core   +1 more source

Reshaping ophthalmology training after COVID-19 pandemic

Eye, 2020
Background The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on practical activities and didactic teaching of residents and fellows.
Mariantonia Ferrara, Vito Romano, David H. W. Steel, Rajen Gupta, Claudio Iovino, E. H. V. van Dijk, Mariantonia Vito Davis H Rajen Claudio Elon H. C. Carlos Ernes Ferrara Romano Steel Gupta Iovino van Dijk Rocha-d, Mariantonia Ferrara, Vito Romano, Davis H Steel, Claudio Iovino, C. Rocha-de-Lossada, E. Bali, X. Valldeperas, Davide Romano, Kunal A. Gadhvi, F. Matarazzo, A. Tzamalis, Piergiacomo Grassi, Rahul Rachwani, Giulia Coco, Catherine Dianne Reyes-Delfino, F. Amoroso, N. Nakhoul, F. Sabatino, Sufiyan Shaikh, A. Au, Emiliano Di Carlo, B. Steger, Andrea Govetto, Mario Toro, Michela Cennamo, S. Demirel, P. Napolitano, C. Cartes, R. Raimondi, Alessio Montericcio, Giancarlo DellʼAversana Orabona, Chiara Comune, D. Borroni, Luca Pagano, Clara Montalbano, Danilo Iannetta, M. Angi, M. Romano   +44 more
semanticscholar   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

The impact of COVID-19 related lockdown on ophthalmology training programs in India – Outcomes of a survey

Indian Journal of Ophthalmology, 2020
Purpose: In 2020, in response to the emergence and global spread of the disease COVID-19, caused by a new variant of coronavirus 2019-nCoV, the government of India ordered a nationwide lockdown for 21 days, which was then extended to a total of over 50 ...
D. Mishra, A. Nair, Rashmin Gandhi, P. Gogate, Satanshu Mathur, P. Bhushan, Tanmay Srivastav, Hemendra Singh, B. Sinha, M. Singh   +9 more
semanticscholar   +1 more source

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Knowledge, understanding and the dynamics of medical innovation [PDF]

This paper investigates the processes by which scientific knowledge is created and legitimized. It focuses on scientific developments in a branch of medicine and explores the pathways through which the growth of knowledge enables advances in medical ...
Consoli, Davide, Ramlogan, Ronnie
core   +1 more source

Lacrimal gland tumors in Turkey: types, frequency, and outcomes. [PDF]

, 2018
AIM: To evaluate the clinical, radiological, and treatment features of lacrimal gland tumors. METHODS: Retrospective review of 99 eyes of 92 patients with lacrimal gland tumors diagnosed and managed in a single institution between January 1999 and March ...
Erden, Esra, Gündüz, Ahmet Kaan, Shields, Carol L., Yeşiltaş, Yağmur Seda   +3 more
core   +2 more sources

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study. [PDF]

, 2018
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients.
Galli, Fabio, Hollander, Lital, Italian Study Group on QoL in Glaucoma, Katsanos, Andreas, Oddone, Francesco, Poli, Davide, Quaranta, Luciano, Riva, Ivano, Rulli, Eliana, Torri, Valter, Weinreb, Robert N   +10 more
core   +2 more sources