Results 81 to 90 of about 27,460 (260)

Uveitis following anti-snake venom therapy

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Snakebite is a common medical emergency in the tropics, causing multisystemic involvement. Ophthalmic manifestations after snakebite have included ptosis and ophthalmoplegia.
S. G. Nayak, R. Satish, S. Nityanandam, R. K. Thomas   +3 more
doaj   +1 more source

Activating AMPK improves pathological phenotypes due to mtDNA depletion

The FEBS Journal, Volume 292, Issue 9, Page 2359-2380, May 2025.
In a cellular model of mitochondrial disease characterized by progressive mitochondrial DNA (mtDNA) depletion, we found that advancing mitochondrial dysfunction triggers the early and specific activation of the mitochondria‐associated pool of AMP‐activated protein kinase (AMPK), a master regulator of energy homeostasis.
Gustavo Carvalho, Tran V. H. Nguyen, Bruno Repolês, Josefin M. E. Forslund, W. M. Ruchitha Rukmal Wijethunga, Farahnaz Ranjbarian, Isabela C. Mendes, Choco Michael Gorospe, Namrata Chaudhari, Micol Falabella, Mara Doimo, Sjoerd Wanrooij, Robert D. S. Pitceathly, Anders Hofer, Paulina H. Wanrooij   +14 more
wiley   +1 more source

Chronic intestinal pseudoobstruction and ophthalmoplegia in a patient with mitochondrial myopathy [PDF]

, 1988
A 38 year old woman having chronic intestinal pseudoobstruction associated with mitochondrial myopathy is reported. The clinical and radiographic features suggested the diagnosis of chronic intestinal pseudoobstruction.
Bayés Rusiñol, Àngels, Blesa González, Rafael, Bruix Tudó, Jordi, Cervera i Segura, Ricard, 1960-, Coll, J., García Pugés, Antonio Manuel, Illa Sendra, Isabel   +6 more
core   +2 more sources

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Ataxia in children: early recognition and clinical evaluation [PDF]

, 2017
Background: Ataxia is a sign of different disorders involving any level of the nervous system and consisting of impaired coordination of movement and balance.
Falsaperla, Raffaele, Lubrano, Riccardo, Pavone, Piero, Pavone, Vito, Praticò, Andrea D., Rizzo, Renata, Ruggieri, Martino   +6 more
core   +1 more source

Exenterate or Not: A Simple Proposed Management Algorithm for Mucormycosis During the Era of COVID-19 in a Tertiary Eye Care Center in Egypt

Clinical Ophthalmology, 2022
Reham Refaat Shabana, Mohamed Ashraf Eldesouky, Hazem A Elbedewy Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Gharbeya, EgyptCorrespondence: Hazem A Elbedewy, Department of Ophthalmology, Faculty of Medicine, Tanta ...
Shabana RR, Eldesouky MA, Elbedewy HA
doaj  

Genetic migraine disorders and the response to calcitonin gene‐related peptide antagonist treatment

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Calcitonin gene‐related peptide (CGRP) is a potent cerebral vasodilator and part of the trigeminal migraine cascade. Newer migraine therapies target CGRP signaling for both acute and preventative management of headache. In this series, we present two cases of genetic conditions, of which migraine is a key feature, responsive to CGRP antagonist
Andrea M. Kuczynski, William S. Kingston
wiley   +1 more source

Erdheim-Chester Disease Presented with Bilateral Carotid Artery Occlusion: Case Report

Türk Nöroloji Dergisi, 2010
Erdheim-Chester disease is a rare, non-Langerhans form of systemic histiocytosis of unknown etiology. The disease affects multiple organ systems, including musculoskeletal, cardiac, pulmonary, gastrointestinal, and central nervous systems, producing ...
Yahya Çelik, Kemal Balcı, Talip Asil, Erdem Tüzün, Mustafa Kemal Hamamcıoğlu, Osman Temizöz, Sait Albayram, Aydın Sav   +7 more
doaj   +2 more sources

Advancements in multiple sclerosis

Internal Medicine Journal, EarlyView.
Abstract The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis and treatment is essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive and degenerative aspects of MS continue to pose major challenges.
Turlough Montague, James Drummond, Karl Ng, John Parratt   +3 more
wiley   +1 more source

Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases [PDF]

, 2008
Background: Paraneoplastic neurological syndromes (PNS) are indirect remote effects of cancer on the nervous system, often associated with the presence of specific serum antibodies.
Hoffmann, L. A., Jarius, S., Pellkofer, Hannah Luise, Schueller, M., Krumbholz, Markus, Koenig, F., Johannis, W., La Fougere, Christian, Newman, T., Vincent, A., Voltz, Raymond   +10 more
core   +1 more source