Results 41 to 50 of about 4,734,907 (276)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

Religiosity of the urban community in Kazakhstan

open access: yesRUDN journal of Sociology, 2020
Religious values as the most important component of the worldview can significantly affect various aspects of human life - from everyday practices to political preferences. The analysis of changes in religiosity shows that in the post-Soviet space, there
G. T. Alimbekova   +2 more
doaj   +1 more source

Scaling limits for continuous opinion dynamics systems [PDF]

open access: yes, 2009
Scaling limits are analyzed for stochastic continuous opinion dynamics systems, also known as gossip models. In such models, agents update their vector-valued opinion to a convex combination (possibly agent- and opinion-dependent) of their current value ...
Como, Giacomo, Fagnani, Fabio
core   +3 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

Interplay between media and social influence in the collective behavior of opinion dynamics

open access: yes, 2015
Messages conveyed by media act as a major drive in shaping attitudes and inducing opinion shift. On the other hand, individuals are strongly affected by peer pressure while forming their own judgment.
Castellano, Claudio, Colaiori, Francesca
core   +1 more source

Recommendation model based on opinion diffusion [PDF]

open access: yes, 2007
Information overload in the modern society calls for highly efficient recommendation algorithms. In this letter we present a novel diffusion based recommendation model, with users' ratings built into a transition matrix.
Blattner M. Laureti P. Huntziker A.   +8 more
core   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Drugwatch: Establishing the Practicality and Feasibility of Using Key Professionals and Illicit Drug Users to Identify Emerging Drug Tendencies

open access: yesForum: Qualitative Social Research, 2007
The updated United Kingdom Anti-Drugs strategy highlights gaps in the current body of drug related knowledge. Although work has been addressing these gaps for a number of years now, it has proven challenging to establish the dynamics of emerging drug ...
Mark Mason, Oswin Baker, Rebecca Hardy
doaj  

Epidemiology of pediatric ocular injuries in Poland: cross-sectional study

open access: yesBMC Ophthalmology
Background Ocular trauma in children results in long-term visual impairments and affects the child’s physical and psychosocial development. The variability in age, gender, and socio-environmental factors significantly determines their epidemiology ...
Ewa Toruńska   +3 more
doaj   +1 more source

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