Results 191 to 200 of about 1,025,460 (276)

Hybrid modeling for optimizing cell cultivation in mAb production using a small‐scale automated experimental platform

open access: yesAIChE Journal, EarlyView.
Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto   +6 more
wiley   +1 more source

Accelerating Surface Composition Characterization of Thin‐Film Materials Libraries Using Multi‐Output Gaussian Process Regression

open access: yesAdvanced Intelligent Discovery, EarlyView.
To integrate surface analysis into materials discovery workflows, Gaussian process regression is used to accurately predict surface compositions from rapidly acquired volume composition data (obtained by energy‐dispersive X‐ray spectroscopy), drastically reducing the number of required surface measurements on thin‐film materials libraries.
Felix Thelen   +2 more
wiley   +1 more source

CrossMatAgent: AI‐Assisted Design of Manufacturable Metamaterial Patterns via Multi‐Agent Generative Framework

open access: yesAdvanced Intelligent Discovery, EarlyView.
CrossMatAgent is a multi‐agent framework that combines large language models and diffusion‐based generative AI to automate metamaterial design. By coordinating task‐specific agents—such as describer, architect, and builder—it transforms user‐provided image prompts into high‐fidelity, printable lattice patterns.
Jie Tian   +12 more
wiley   +1 more source

The Necessity of Dynamic Workflow Managers for Advancing Self‐Driving Labs and Optimizers

open access: yesAdvanced Intelligent Discovery, EarlyView.
We assess the maturity and integration readiness of key methodologies for Materials Acceleration Platforms, highlighting the need for dynamic workflow managers. Demonstrating this, we integrate PerQueue into a color‐mixing robot, showing how flexible orchestration improves coordination and optimization.
Simon K. Steensen   +6 more
wiley   +1 more source

Advanced Experiment Design Strategies for Drug Development

open access: yesAdvanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang   +3 more
wiley   +1 more source

Comparison of DeePMD, MTP, GAP, ACE and MACE Machine‐Learned Potentials for Radiation‐Damage Simulations: A User Perspective

open access: yesAdvanced Intelligent Discovery, EarlyView.
The authors evaluated six machine‐learned interatomic potentials for simulating threshold displacement energies and tritium diffusion in LiAlO2 essential for tritium production. Trained on the same density functional theory data and benchmarked against traditional models for accuracy, stability, displacement energies, and cost, Moment Tensor Potential ...
Ankit Roy   +8 more
wiley   +1 more source

Large Language Model‐Based Chatbots in Higher Education

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of large language models (LLMs) in higher education can facilitate personalized learning experiences, advance asynchronized learning, and support instructors, students, and researchers across diverse fields. The development of regulations and guidelines that address ethical and legal issues is essential to ensure safe and responsible adaptation
Defne Yigci   +4 more
wiley   +1 more source

Machine Learning‐Based Estimation of Experimental Artifacts and Image Quality in Fluorescence Microscopy

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of image quality metrics in combination with machine learning enables automatic image quality assessment for fluorescence microscopy images. The method can be integrated into the experimental pipeline for optical microscopy and utilized to classify artifacts in experimental images and to build quality rankings with a reference‐free approach ...
Elena Corbetta, Thomas Bocklitz
wiley   +1 more source

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