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Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

Anaesthesia, EarlyView.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe, Martha Belete, Adam B. Brayne, Harriet Daykin, Matthew Everson, William M. Hare, Katy Samuel, Lexy Sorrell, the POPPY Study Delivery Group, Katie Samuel, Xiaosu Jiang, Hayaka Amada, Lisa Ditchfield, Nkiruka Obiakpolam, Rebekah Chan, Lauren Mahoney, Rebecca Madew, Kristian Tattam, Shannon Collings, Harry Bamber, Lee Baines, Michael Thurm, Gearoid Crosbie, Felicity Hamilton, K. Hempenstall, Rabiat Umar, Alicia Ibbotson, Jolyon Flint Cahan, Tushar Das, Stuart Evans, Davina Hewitt, Sian Mckee, Joe Mellor, Mathew Patteril, Dawn Davies, Shiji Thomas, Jesty Thomas, Charlie Bevan, Natalie Kenny, Fenella Podd, Sindhu Sapru, Shilani Sundaram, Richie Field, Ellie Whittingham, Ben Wilkinson, Geetanjali Verma, Jayne Sewell, Grace Killingsworth, Sapna Chakranarayan, Beverley Wilkinson, Patricia Nicholls, Irfan Ulhaq, Mudola Manyano, Myo Thet Paing Lin, Katherine Davidson, Jane Gregory, Zoe Saunders, Rhona Bill, Antoinette Wilson, Diane Armstrong, Aku Iboroma, Abhinav Kant, Holly Davies, Manabendra Haldar, Ben Thompson, Myra Khan, Thomas Ballance, Sarah Cook, Matthew Stokle, Abby Minette, Tori Hanson, Marilyn Cooper, Natasha Mulley, Jerry Thomas, Georgina Chapman, Luke Patterson, Renjith Joseph, Praveen Gunasekaran, Dorota Potoczna, Lindsey Bennett, Kathy Dent, Kirsty Nauyokas, Sandra Pearson, Sue Spencer, Bahaael Din El Sady, Jenetha Rajendram, Annie Wood, Keiran Dudden, Caroline Kane, Sophia Hamilton, Dipayan Choudhuri, Peter Sykes, Florence Emond, Florian Fischer, Ian Edmond, Ryad Chebbout, Iona Lennie, John Ochiltree, Maria Blaney, Thalia Massa, Srinivas Magham, Ankit Kedia, Vaisakh Viswanathan, Saqib Khan, Malathi Jabanathan, Eleni Grani, Rosemary Harper, Anna Pierson, Nomonde Laxa, Allan Clark, Chinenyenwa Amaraihe, Christopher Dixon, Haneefa Ali, Purnima Narasimhan, Jessica Biggs, Keslin Greenwood, Bhavesh Gohil, James Lamert, Michael Sawaryn, Alice Gao, Lynden Nicely, Ruth Parker, Ismail El‐Kharbotly, Zheyna Konstantinova, Bilal Afzal, Abu Kalam, Holly Mcquarrie, Shuaib Sheikh, Muhammad Furqan, Praveena Chand, Freddie Weyman, Sofia Theodoridou, Fotios Gkioulos, Laura Fulton, Benjamin Cooper‐Drake, Asya Veloso Costa, Edward Gill, Laura Edwards, Henry Somers, George Budden, Deirdre Guerin, Kim Jemmett, John Cockcroft, Ahmed Hassan, Arisa Reka, Eleanor Plews, Jack Whiting, Richard Buckley, Reanne Solly, James Rand, Sarah Stirrup, Emma Ingall, Olajumoke Owolabi, Sabeen Tufail, Sindu Sridhar, Victoria Fisher, Kimberley Netherton, Amy Faunt, Jane Upsall, Daniel Stolady, Karan Verma, Sian Liddle, David Chapman, Stefan Kourdov, Daniel Jafferji, Jayakadumudiyanselage Jayakadu, Nikhil Singh, Udara Wickramanayake, Zi Soo, Hannah Neil, Johannes Retief, Kelly Barrett, Catherine Marshall, Alice Cato, James Norton, Kirsty Pearce, Oliver Main, Isabelle Mayne, Sophy Booth, Daisy Flanagan, Laura Helley, Jordan Hargreaves, Bethan Morgan, Victoria Maples, Nour Shubber, Claire Stringer, Noori Suhail, Samuel Small, Charlotte Beresford, Hoi Ching Fung, Rebecca Parker, Amy Szuman, Heather MacFarlane, Loveleena Gupta, Bunyad Naqvi, Harry Holkham, Islam Ahmed, Daniel Slane, Basant Bhattari, Vincent Chan, Abby Collins, Dean Wilkinson, Jessica Jones, Joanna Renée, Ross Gillespie, éireann Allen, Jakub Foytl, Alexandra Vine, Lucy Dobbs, Matthew Dunne, Anna Boyer, Judith Highgate, Marten Lau, Tanmay Jain, Mennatuallah Khedr, Mohamed Abdo, Ahmed Aboelezz, Sarah Goodwin, Adam Pickard, James Cartwright‐Gill, Matthew Cadd, Rory Mercer, James Andren, Sampson Anya, Alice Hipsey, Tom Searle, Amr Elmosalamy, Mennatu‐Allah Khedr, Tanya Hossain, Danielle Simpson, Juliette Kemp, Vanessa Badas, Matthew Lettis, Charlotte Jewell, Thomas Doel, Charles Kennedy, Caroline Wrey Brown, Emily Bevan, Maria Alvarez Corral, Joanna Moon, Kerry Taylor, Joanna Simpson, Clare Bird, Femi Adetunji, Nipun Mundkur, Lynsey Crowley, Emma Williams, Edyta Klata, Kerry Smith, Alison Ghosh, Katrina Cooke, Aashima Bakshi, Hannah Stansfield, Chiara Delenadis, Andrew Veal, Michael McGovern, Helena Dunn, Stella Gillies, Sarah El‐Sheikha, Clare Buffery, Emily Robinson, Anya Sheltawy, Ian Turner‐Bone, Laura Wilding, Harriet Murrant, Michaela Lloyd, Andrew Martin, Chris Jones, Elizabeth Whatling, Rachael Reddall, Kathrine Redington, Poppy Jenkinson, Fouad El‐Hibri, Berenice Cunningham‐Walker, Rachel Kearns, Iain Mactier, Munsoor Latif, Rowan Swan, Mina Zikry, Nicholas Yeo, Sarah Meredith, Emily Black, Kirsty McCrorie, Tom Baddeley, Clarissa Hocking, Faith Dalgatty, Simon Chitnis, Garry Davenport, Lisa Grimes, Georgina Singleton, Parameswari Chockalingam, Zarah Brown, Sabari Karthick Kumar, Lucy Miller, Benjamin Holdstock‐Brown, Oliver Totham, Nitya George, Priti Morzaria, Sachintha Hewage, Joseph Pease, Oliver Francis, Caroline Phillips, Vladimir Bashliyski, Rajan Mehta, Gabrielle Mendez, Alun Thomas, Elizabeth Henderson, Becky Icke, Charlotte Jones, Bethan Morse Browning, Bethan Landeg, Kevin Scott, Fiona Morris, Thomas Rae, Konara Mudiyanselage Ishan Madhuwantha Dharmarathna, Yuvaraj Doraiswamy, Lewis Isaac, Trudy Smith, Tracey Lewis, Linda O’Brien, Emma Perkins, Sunita Agarwal, Farah Nizar, Ibrahim Mostafa, Michelle Edwards, Erin Williams, Randeep Dhaliwal, Pawan Kootelu Pernu, Jane Doherty, Stephy Jose, William Flesher, Catriona Laverty, Abirami Kanniappan, Ikechukwu Igwebuike, Ramy Howaidi, Thomas Pinnock, Gabriel Ngui, E. 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Clutterbuck, Sarah Davies, Sabba Aziz, Sarah Beckley, Sunil Chaurasia, Thomas Smith, Lauren Pout, Nicholas Smith, Hannah Winder, Jennifer Butler, Lizzie Ribey, Paul Bramley, Kate Gamble, Jane Booker, Anna Galvin, Alice Nicholson, Tamsin Gregory, Charlotte Dowson, Nicholas Yu, Liz Shenton, Kellie Butterfield, Ginny Clarke, Helen Henson, Lindsey Stephens, Lisa Armstrong, Marcela P. Vizcaychipi, Laura Martins, Jaime Carungcong, Kribashnie Nundlall, Florison Canlas, Emily Futter, Carina Bautista, Rhian Bull, Julie Logan, Alexandra Schookmeesters, Patricia Costa, Katharine Balfour, Patrizia Simonato, Ilhan Wardhere, Tamsyn Glover, Ben Wooldridge, Claudia Gardiner, Samuel Worsley, Penny Parsons, Camilla Stagg, Judy Shirley, Angela Day, Inderjit Atwal, Sundar. Raj Ashok, Shilen Shah, Eram Majeed, Sonali Mohite, Daniel King, Lucy Partridge, Edward Hare, Nuwan Dahanayake, Islam Abousharkh, Thisaru Wellalage, Vlera Qerkezi, Meenu Payyappilly, Harriet Gardiner, Karen Stacey, Jonathan Dunne, Sadia Habib, Sanooj Soni, Stephanie Ivie, Emily Russell, Elaine Viloria, Eliza Speranzini, Maura Roy, Kim Rhodes, Anukriti Panda, Olumayowa Ogunwemimo, Quoc Nguyen, Dineesha Menon, Chiwen Lin, Lija Joy, James Emerton, Mark Caballes, Lauren Whitestone, Emily Rosewood, Surpreet Grewal, James P. Ruddy, J. P. Ruddy, Audrey McAlpine, Roisin McGovern, R. Adam, Catriona Anderson, S. Julius, Peter Sandbach, Su‐Mei Tham, Muhammad Azeem, Mirac Demirbag, Amr Youssef, Mostafa Salaheldeen Mohammed, Christopher Wild, Rebecca Flanagan, Emma McKenna, Elena Apetri, Scott Latham, Danielle Hollick, Robert Davidson, Nidhi Gautam, Rakhi Ghosh, Mary James, Darryl Braier‐Lorimer, Darshana Ranasinghe, Vitor Goncalves Savoia, Rajesh Shankar, Shahid Johar, Jasmin Pandhal, Xiaobei Zhao, Jincy Joseph, Alice Mihaela Balaican, Reuly Vicente, Jackie Evans, Ahashia Qureshi, Chimenime Ede, Ogwa Tobi, Luke Hoskins, Mike Blundell, Lucy Reid, Ellie Granger, Samuel Dale, James Bennett, Nina Llewellyn, Samuel Gowshall, Shivraj Patel, Haytham Lebari, Anna Surridge, Chris Pennington, Nishaan Nayar, Mo Williams, John O’Rourke, Barbara Ribeiro, Harriet Carter, Laura Griffiths, Ben Richardson, Claudia Dyball, Jo Ingham, Dan Wise, Adulrhman Abelmagd, Charlotte Henson, Amy Gomes, Hannah Foster‐Rain, Ashiq Mohamed Salim, Sunil Jeevan Dasari, Amin Elkhawad, Khadija Ranjha, Robert Stroud, Anushka Sieunarine, Iain McLure, Kathryn Simpson, Matthew Cole, Alistair Gales, Amy Nixon, Mohammed Mahgoub, Tom Woodhouse, Natasha Jones, Louise Leonard, Elizabeth Mcgough, Olivia Tiley, Ranya Alias, Charlotte Eglinton, Kerry Paradowski, Michaela Cox, Karen Rahilly, Gail Williams, Matthew Forester, Ciprian Cociuba, Chris Perry, Amy Yeoman, Dagmar Holmquist, Stephen Daly, Zara Al‐Faham, Ehmed Chohan, Karim Tawfik, Zoheir Boutaleb, Daniel Crossman, Ahmed Aly, Tim Warrener, Shun Yamanaka, Victoria Hodgson, Charlotte Williams, Julie Alderton, Rachel Franklin, Abigail Patrick, Eden Wildman, Johanne Hamilton, Gabriella Smallwood, Pinky Thu‐Ta, Glen Marsh, Francesca Onofri, Chris Gordon, Angela Downing, Heidi Hollands, Fiona Reed, Tracy Ward, Noah Boateng, Natasha Wilmshurst, Paola Vasconcelos, Ada Nweze, Lisa Shainberg, Samuel King, Amit Das, Elaine Freeman, Katie Latham, Liam Kitto, Sheena Melendrez, Emma Abraham, Victoria Yates, Simon Clark, Laura Garner, Fiona Elliot, Jyothi Hosahalli Lakshmanachar, Elena Marco Illana, Rincy Kurian, Louise Pyrkos, Catherine Willshire, Roberta Depretto, Sivaprakash Vaitheeswaran, Julie Knight, Kristina Doab, Claire Palombo, Gbemisola Jenfa, Tariq Chaudhari, Jozen Obrique, Rhidian Jones, Lara Jesani, Sophie Jones, Thomas Wand, Robert Wight, Lucy James, Tristan Hawkins, Rhiannon Harling, Lauren Nunnerley, Alysha Hancock, Sudha Garg, Jonathan Bates‐Powell, Aparesh Mandal, Harrison Plumpton, Uzma Khan, Kevin Howard, Jane Woods, Elva Wilhelmsen, Darylile Guledew, Julie North, Cherry Ann White, Wendy Harrison, Donna Griffiths, Helen Sutherland, Amy Garrod, Charlotte Kelly, Manjunatha S. V. Patel, Carolyn Smith, Swarnendu Dey, Vivek Trivedi, Robert Brown, Raeesa Patel, Danielle Teasdale, Aidan Butler, Tanvi Ujoodha, Melanie Taylor, Ashleigh Lovett, Adam Mosley, Katherine Pagett, Ifan Teifi Rees, Alison Tucker, Ellen Mary Knights, Jeannie Bishop, Sion Lewis, Abhik Bhattacharjee, Alice Chubb, Cyrille Cabaret, Katrine Thorup, Miles Seavill, Seray Gunes, Alex Mattin, Bethany Goulson, Kilda Carpenter, Rebecca Lee, Joanne Fong, Geraldine Hambrook, Ben Chandler, Bhavya Janardhana, Alex Dunn‐Roberts, Janine Armstrong, Kerry Elliott, Laura Barman, Alison Turnbull, Anna Waine, Dana Groom, Rachel Harrison, Agnieszka Kubisz‐Pudelko, Jennifer Driver, Lucy Pippard, Linda Howard, Karl Fuchs, Nigel Beer, Alison Lewis, Kate Beesley, Jess Foster, Mark Giza, Joyce Yeung, Mithila Govindaraju, Arlo Whitehouse, Mehwaish Zulfiqar, Jo Gresty, Celina Maliaykal, Ellie Reeves, Kyrie Wheeler, Shreevastchavan Rajasekar, Rifah Zia, Amrish Gujrathi, Sharique Anwar, Heather Willis, Faye Moore, Elizabeth Martin, Helena Purle, Sumeya Faysal, Balkrishna D. Nimavat, Alexandra Clement, Rohit C Sheth, Margaret Carmody, Sam Staffod, Karthik Vasudevan Iyer, Bryan Wong, Tammy Bellamy, Teresa Melody, Emily Butler, Clifford Shelton, Stephanie Teh, Arosa Lin Lok Heng, Emily Coffey, Samantha Moore, Jonathan Casson, John Schutzer‐Weissmann, Maxime Caron‐Goudreau, Lucy Liu, Anish Thillainathan, Mike Frow, Wing Sze Sara Hui, Zara Eagle, Thomas J Craig, Anthony Carver, Archana Depala, Nile Sharma, Sean O’Reilly, Nick Moss, Lawrence Rory Kidd, Rasangi Suraweera, Katy Lee, Alexander Rond‐Alliston, Kayleigh Collins, Sahil Gupta, Hannah Swinburne, D Sean Cope, Martyn Ezra, Songtum Saltrese, Charlotte Jenkins, Aarif Ali, Kulpdeep Nijjar, Yanisa Wannasuphoprasit, Sneha Gurung, Serina Sidhu, Reet Nijjar, Sioned Phillips, Kerry Fisher, Caroline Fryer, Lorinda Essuman, Girgis Abadi, James Bigley, Tamanna Shikh‐Bahaei, Rachel Mills, Ceri‐Ann Brigid Lynch, Sioned Davies, Katy Gilbert, William Dace, Kaitlyn Egan, Sammy Sharif, Amy Wright, Lucy Griffin, Elliot Phillips, Stella Arthur‐Quarm, Zak Deere, Steffan Morgan, Kiri Armstrong, Anya Jones, Pallavi Dasannacharya, Adam Green, Francesca Elwen, Charlie Brock, Chris Watson, Nishanth Sandrasegaram, Patrice Forget, Emma Rhodes, Amanda Gould, Onyinyechi Oziogu, Fiona Rixon, Nicola Price, Karen Norris, Vicky Taylor, Lynn Mackay, Oliva Hitch, Marc Place, Kirsty Bromley, Andrew Hunter, Sarah‐Anne Milne, Li Lin Hong, Alistair Morris, Kebba Konteh, David Ford, Chisomo TengaTenga, Chia‐Ping Chou, Sophie Lubbock, Julie Grundy, Anju Thomas, Cecilia Peters, Kathleen Holding, Shifa Patel, Alison Chambers, Lois Daniels, Thomas Swainstone, Barbara Nowicka, Julia Sampson, Andrew Clark, Scott Calvert, Collette Burns, Danielle Gilmour, Mark Wilson, Debbie Callaghan, Patrick Thorburn, Hajnalka Huszka, Matthew Farrant, Juliet Ariel, Ahmed Yousef, George Gathercole, Cicely Culmer, Ranvir Singh, Johnlee Joseph Kuragala, Lavanya Thakur, Arpan Sashankar, Jean Kinder, Heather Savill, Avril Lee, Lilian Eze, Martyn Clark, Martina Coulding, Roxanne Gray, Chris Coppletone, Lizzie Freeman, Alison Gordon, Perumbadage Tharanga Prasad Gunarathna, Rory J. Heath, William Hughes, Samuel McAleer, Stuart McPhail, Felix Robins, Jessica Sinclair, Luke Solomi, Joanna Wilson, Thomas Woodward, Yun Chi Yu, Elliot Catchpole, Aparna Cockrell, Emma Lang, George Linfield‐Brown, Helmi Burton‐Papp, Matt Duffield, Emma Killick, Kate Edgeley, Claudia Lameirinhas, Chand Ishwin, Clarissa Metz, Karen Hudson, Suresh Kondi, Nicole Sproul, Rhoda Odeyemi, Nadine Darnley, Michael Salloum, Vivek Kumar Sinha, Sarah Jayne Beresford, Jack Haslam, Sheila Munt, Louise Howard‐Sandy, Rebbekka McCullough, Jennifer Kujacz, Fathy Elshazly, Imran Riasat, Andrew Baigie, Fiona Ramsden, Gabrielle Grounds, Roxana Sandhar, Julian Giles, Tracey Shewan, Gail Pottinger, Sophie Holden, Christian Balajadia, Melanie Hutchings, Linda Park, Tania Nightingale, Thomas Boddington, Rachel Kelland, Joanna Czylok, Timothy Richards, Nicholas Aveyard, Kevin Windsor, Shemin Kovammal, Adeela Muzaffar, Raman Mobasheri, Uashar Badakhshan, Rob James, Sophie Knipe, Phoebe Olabode, Ben Curry, Liam Longville‐smith, Charles Gregory, Sulakshan Ranaweera, Christopher Timmis, Jacyntha Khera, Farooq Brohi, Mohammed Aleem, Magdalena Stefaniak, Sarah Easby, George Greig, Mohamed Abdelsalam, Carol Adams, Ana Teixeira, Sarah Purvis, Nicole Harris, Fe Hernandez, Susan Crawford, Eve Wilson, Anna Rookes, Simon Sinclair, Elaine Siddle, Barbara, Deborah Wilson, Hillie Corr, Helen, Konstantinos Miltsios, Muska Miller, Evelina Russell, Brian Herath, Sangita Kindred, Giada Bitente, Lily Kirkpatrick, Chinwe Obiozo‐Jumbo, Latifah Harris, Kayleigh Gilbert, Vikas Vijay Tripurneni, Sian See Tan, Aastha Chawla, Ben Shelley, Alfie Lloyd, Gary Paul, Claire Twomey, Ben Shelley, Aditya Kuravi, Klaus Mahler, Matthew Byrne, Emma Sherry, Mukundan Ramanujam, Sohail Bampoe, Iby Adedugbe, Yuhan Peng, Mohammed Khaku, Dona Saha, Amalia Priovlou, Deborah Smyth, Georgia Bercades, Chimverly Diaz, Gladys Martir, Ingrid Hass, Laura Gallagher, Maria Zapata Martínez, Karen Beaumont, Donna Durrant, Thomas Bate, Katherine Whitely, Beata Buga, Mark Rockett, on behalf of the Research and Audit Federation of Anaesthetists in Training, Gianluca Trisolini Longbardi, Helen Iliff, Brett Doleman, Jonathan Barnes, Katie Preston, Thomas Davies, Sarah Hudson, Adam Boulton, Aravind Ramesh, Jonathan Bower, Suzanne Harrogate, Swati Gupta, Tom Baumer, Yolande Squire, Calum Taylor, Oliver Barker, Carys Lim, Kathleen Wolff, Chiu Lee, Sophia Beeby, William Denehan, James Ward, Mayur Murali, Matthew Luney, Elliot Yates, Christopher Dixon, Matthew Baldwin, Beth McElroy, Elizabeth Thompson   +2083 more
wiley   +1 more source

Effect of esketamine-based opioid-sparing anesthesia strategy on postoperative pain and recovery quality in patients undergoing total laparoscopic hysterectomy: A randomized controlled trail

Heliyon
Objective: Opioid-sparing anesthesia reduces intraoperative use of opioids and postoperative adverse reactions. The current study investigated the effect of esketamine-based opioid-sparing anesthesia on total laparoscopic hysterectomy patients' recovery.
Jialei Liu, Jiangwen Yin, Jieting Yin, Menghan Zhou, Long Chen, Xiwei Dong, Yan Li   +6 more
doaj   +1 more source

Meta‐Analysis: Prevalence and Incidence of Gastroparesis Following Lung or Heart Transplantation

Alimentary Pharmacology &Therapeutics, EarlyView.
Gastroparesis occurs in nearly one‐third of lung and heart‐lung transplant recipients (pooled prevalence 31.9%; incidence 25.7%), driven by surgical complexity, perioperative opioid exposure, and diagnostic criteria. Standardized gastric emptying assessment and multidisciplinary management, including opioid minimization, immunosuppressant optimization,
Mohamed H. Eldesouki, Mohamed Mahmoud Marey, Mohamed Ahmed Ali, Amany Mahmoud Genidy, Mohamed Hesham Gamal, Ali M. Othman, Ahmed N. Mohamed, Ahmed Al Qady, Manuel A. Amaris, Amol Sharma   +9 more
wiley   +1 more source

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis

International Journal of Hyperthermia, 2019
Background: Studies suggest volatile anesthetics and opioids may enhance the malignant potential of cancer cells. The objective of this single institution retrospective study was to evaluate the survival impact of a multimodal opioid-sparing nonvolatile ...
Juan P. Cata, Linh T. Nguyen, Ifeyinwa C. Ifeanyi-Pillette, Antoinette Van Meter, Lori A. Dangler, Lei Feng, Pascal Owusu-Agyemang   +6 more
doaj   +1 more source

Survey describing the perspectives and practices of Australian veterinarians to pain management in horses

Australian Veterinary Journal, EarlyView.
Objective To describe Australian practices and attitudes regarding equine analgesia. Study Design Cross‐sectional anonymous, voluntary survey of Australian veterinarians treating equine patients. Methods Australian veterinarians in equine or mixed practices completed a six‐section, 60‐question survey between November 2019 to August 2020.
A Whitelock, W Goodwin, L Dryburgh, PP Mshelbwala, L Rae, L Marwedel, T Lok, K Kemp, AJ Stewart   +8 more
wiley   +1 more source

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source