Results 31 to 40 of about 1,505,677 (242)

Using Twitter to Surveil the Opioid Epidemic in North Carolina: An Exploratory Study

JMIR Public Health and Surveillance, 2020
BackgroundOver the last two decades, deaths associated with opioids have escalated in number and geographic spread, impacting more and more individuals, families, and communities. Reflecting on the shifting nature of the opioid overdose crisis, Dasgupta,
Anwar, Mohd, Khoury, Dalia, Aldridge, Arnie P, Parker, Stephanie J, Conway, Kevin P   +4 more
doaj   +1 more source

Digital Interventions to Save Lives From the Opioid Crisis Prior and During the SARS COVID-19 Pandemic: A Scoping Review of Australian and Canadian Experiences

Frontiers in Public Health, 2022
BackgroundThe potential for digital initiatives for opioid harm reduction is boundless. Synthesized evidence on current interventions and their efficacy are emerging.
Andrea Donnell, Chandana Unnithan, Jessica Tyndall, Fahad Hanna   +3 more
doaj   +1 more source

UNODC Integrated strategy on the global opioid crisis. [PDF]

, 2018
Recent years have seen a sharp rise globally in opioid overdose deaths. Currently, the majority of the world burden of disease caused by drug use disorders is attributable to opioid use.

core  

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

Fusing Administrative Data to Combat the Opioid Crisis

International Journal of Population Data Science, 2018
Opioid-related overdose deaths remain the leading cause of unintentional injury fatalities in the United States.  State lawmakers have responded to this crisis by establishing a regulatory environment that extends various legal protections to persons who
Kevin P Conway, Camille Gourdet
doaj   +1 more source

Positive Affect Is Associated With Better Physical Function in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir, Jing Song, Lutfiyya N. Muhammad, Wendy Marder, Kevin Deane, Clifton Bingham, Lisa A. Mandl, Robert Edwards, Judith T. Moskowitz, Yvonne C. Lee   +9 more
wiley   +1 more source

The double opioid crisis: A call for balance [PDF]

Pharmacoepidemiology and Drug Safety, 2019
In this issue of Pharmacoepidemiology and Drug Safety, several research papers address the safe and appropriate use of opioids. This is important, given the critical situation on opioid use in the United States (US). According to preliminary data from the Centers for Disease Control and Prevention (CDC), more than 72 000 people in the United States ...
Marjolein J.M. Vranken, Marie‐Hélène D.B. Schutjens, Aukje K. Mantel‐Teeuwisse   +2 more
openaire   +4 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Empowering Pharmacists: Strategies for Addressing the Opioid Crisis through a Public Health Lens

Pharmacy
Background: The opioid crisis in the US is a severe public health issue, prompting pharmacists to adopt various strategies for prevention, harm reduction, treatment, and recovery. Despite progress, barriers persist. Results: This commentary examines five
Tamera D. Hughes, Juliet Nowak, Elizabeth Sottung, Amira Mustafa, Geetha Lingechetty   +4 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source