Results 331 to 340 of about 2,513,925 (427)

Profiling the proximal proteome of the activated μ-opioid receptor. [PDF]

Nat Chem Biol
Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R.   +16 more
europepmc   +1 more source

Laryngeal Cancer in the West of Scotland 2014–2020: Trends and Survival in a Cohort of 867 Patients

The Laryngoscope, EarlyView.
This retrospective cohort study of 867 patients with laryngeal squamous cell cancer (LSCC) in the West of Scotland (2014–2020) found a 5‐year overall survival rate of 46%, with glottic cancers having better outcomes (64%) compared to supraglottic cancers (36%). This study also found an increase in the presentation of supraglottic cancers over the study
Rhona Hurley, Claire Paterson, David I. Conway, Gareth J. Inman, Catriona M. Douglas   +4 more
wiley   +1 more source

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. [PDF]

Nature
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C.   +11 more
europepmc   +1 more source

Landscape of informed consent practices and challenges in point‐of‐care clinical trials

Learning Health Systems, EarlyView.
Abstract Point‐of‐care trials, an approach to trial design that assesses medical product effectiveness while fully integrating research and care, represent a promising opportunity to generate practically relevant evidence efficiently for priority disease areas.
Caleigh Propes, Trevan Locke, Rachele Hendricks‐Sturrup   +2 more
wiley   +1 more source

Aligning forces to accelerate healthcare transformation: Insights from the UPMC learning community

Learning Health Systems, EarlyView.
Abstract Introduction To accelerate transformation toward value‐based, equitable care, health systems need a viable approach for engaging and aligning multiple stakeholders to promote innovation. Building and sustaining learning communities offers one possible solution.
Diane Holder, Donna Keyser, Jane Kogan, Matthew O. Hurford, John Lovelace, James Schuster   +5 more
wiley   +1 more source

Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists. [PDF]

Molecules
Guo Y, Yu R, Zhang T, Ren F, Yu Z, Cheng J, Jia H, Shi W, Zhang Y.   +8 more
europepmc   +1 more source

A learning health system model for addressing substance use: Denver Health Center for Addiction Medicine

Learning Health Systems, EarlyView.
Abstract Introduction Substance use disorders (SUDs) continue to place heavy burdens on patients, health systems, and communities. Rapidly evolving treatment for SUDs requires health systems that can efficiently and effectively assess data and integrate evidence to practice.
Emily Bacon, Laura J. Podewils, Brooke Bender, Joshua Blum, Christian Thurstone, Alia Al‐Tayyib, John Mills, Alexandra R. Tillman, Judith Shlay   +8 more
wiley   +1 more source

Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus. [PDF]

BMC Nephrol
Spencer RH, Noonan PK, Marbury T, Menzaghi F.   +3 more
europepmc   +1 more source

Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF))

, 1998
Joel Gelernter, Henry R. Kranzler, James Lacobelle   +2 more
openalex   +1 more source

Cyclical medication management interventions in health care settings: A systematic review

Learning Health Systems, EarlyView.
Abstract Introduction It is estimated that one in 30 patients experiences at least one preventable medication‐related harm while receiving care. Cyclical medicine improvement interventions, where health systems continuously collect data, implement prescribing/dispensing interventions, review outcomes, and revise the intervention, have demonstrated ...
Isabelle Meulenbroeks, Crisostomo Mercado, Rachel Urwin, Karla Seaman, Anna Kelly, Osman Qadri, Johanna Westbrook I.   +6 more
wiley   +1 more source