Results 351 to 360 of about 2,594,817 (409)
Some of the next articles are maybe not open access.
Opioid Peptides and their Receptors
1982The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz +2 more
openaire +2 more sources
2021
Opioid receptors, beyond their involvement in pain transmission, play a number of relevant physiological roles in the central nervous system and in peripheral organs. Opioid receptors can be considered a crossroads where endogenous opioid peptides and foreign opioids and opiates meet the cell and transmit their messages to another vast array of ...
openaire +1 more source
Opioid receptors, beyond their involvement in pain transmission, play a number of relevant physiological roles in the central nervous system and in peripheral organs. Opioid receptors can be considered a crossroads where endogenous opioid peptides and foreign opioids and opiates meet the cell and transmit their messages to another vast array of ...
openaire +1 more source
Opioid receptors and endogenous opioid peptides
Medicinal Research Reviews, 1991The field to be reviewed is now 16 years old and is based on knowledge dating back centuries. It is therefore evident that an exhaustive review is impossible. The author plans to discuss areas likely to be of interest to the readers of this journal.
openaire +2 more sources
Opioids, Receptors, and Immunity
1993The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune system, the extent and significance of ...
M W, Adler +4 more
openaire +2 more sources
Oligomerization of opioid receptors
Methods, 2002Opioid receptors belong to the family of G-protein-coupled receptors characterized by their seven transmembrane domains. The activation of these receptors by agonists such as morphine and endogenous opioid peptides leads to the activation of inhibitory G-proteins followed by a decrease in the levels of intracellular cAMP.
Ivone, Gomes +3 more
openaire +2 more sources
NeuroMolecular Medicine, 2004
Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The
openaire +2 more sources
Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The
openaire +2 more sources
Current Protocols in Pharmacology, 1998
AbstractOpioid receptors mediate the pharmacologic actions of morphine‐like analgesics, a class of drugs that are important clinical agents which are also widely abused socially as a result of their euphorogenic and addictive properties. Cloning of the opioid receptors has confirmed the original postulate that there are only three classes of opioid ...
openaire +2 more sources
AbstractOpioid receptors mediate the pharmacologic actions of morphine‐like analgesics, a class of drugs that are important clinical agents which are also widely abused socially as a result of their euphorogenic and addictive properties. Cloning of the opioid receptors has confirmed the original postulate that there are only three classes of opioid ...
openaire +2 more sources
Pharmaceutisch Weekblad Scientific Edition, 1990
A receptor site is considered to be a transducing factor for effect of the natural ligand. Endorphins and the drugs that mimic their effects (the opiates) are important for analgesia, and consequently the receptor sites involved in actions of opioid drugs are to be considered as relevant to the transmission of pain.
openaire +2 more sources
A receptor site is considered to be a transducing factor for effect of the natural ligand. Endorphins and the drugs that mimic their effects (the opiates) are important for analgesia, and consequently the receptor sites involved in actions of opioid drugs are to be considered as relevant to the transmission of pain.
openaire +2 more sources
2015
The human μ-opioid receptor gene (OPRM1), due to its genetic and structural variation, has been a target of interest in several pharmacogenetic studies. The μ-opioid receptor (MOR), encoded by OPRM1, con- tributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and ...
openaire +2 more sources
The human μ-opioid receptor gene (OPRM1), due to its genetic and structural variation, has been a target of interest in several pharmacogenetic studies. The μ-opioid receptor (MOR), encoded by OPRM1, con- tributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and ...
openaire +2 more sources
Opioid receptors and opioid pharmacodynamics
2005Abstract Opioids have a long and rich pharmacology. They are widely used throughout medicine and have been invaluable. However, they come with problems, including side effects such as constipation, respiratory depression and sedation, as well as the potential of abuse.
Mellar P Davis, Gavril W Pasternak
openaire +1 more source