Results 351 to 360 of about 2,513,925 (427)

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Opioids and the Gastrointestinal Tract: The Role of Peripherally Active µ-Opioid Receptor Antagonists in Modulating Intestinal Permeability. [PDF]

Am J Gastroenterol
Lacy BE, Cangemi DJ.
europepmc   +1 more source

Transurethral Fulguration of Hunner Lesion Was Effective for Primary Management of Pelvic Pain in Patients With Interstitial Cystitis: A Long‐Term Follow‐Up Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective This study aimed to analyze the outcomes of clinical management of patients with interstitial cystitis (IC). Patients and Methods We retrospectively analyzed the electronic medical records of patients with IC who visited outpatient clinics with pelvic pain between October 2005 and December 2019.
Hyun Ju Jeong, Yu Jin Kang, Min Soo Choo, Seong Jin Jeong, Seung‐June Oh   +4 more
wiley   +1 more source

Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening. [PDF]

J Med Chem
Puls K, Olivé-Marti AL, Hongnak S, Lamp D, Spetea M, Wolber G.   +5 more
europepmc   +1 more source

Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator. [PDF]

Nat Commun
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I.   +6 more
europepmc   +1 more source

Chronic Morphine Induces Adaptations in Opioid Receptor Signaling in a Thalamostriatal Circuit That Are Location Dependent, Sex Specific, and Regulated by μ-Opioid Receptor Phosphorylation. [PDF]

J Neurosci
Jaeckel ER, Herrera YN, Schulz S, Birdsong WT.   +3 more
europepmc   +1 more source

Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development. [PDF]

Molecules
Li Z, Huang R, Xia M, Chang N, Guo W, Liu J, Dong F, Liu B, Varghese A, Aslam A, Patterson TA, Hong H.   +11 more
europepmc   +1 more source

Cryo-EM structure of small-molecule agonist bound delta opioid receptor-G_i complex enables discovery of biased compound. [PDF]

Nat Commun
Cheng L, Miao Z, Liu S, Li Z, Fu H, Xu C, Hu S, Zhao C, Liu Y, Zhao T, Liu W, Wang H, Liu R, Yan W, Tang X, Liu J, Shao Z, Ke B.   +17 more
europepmc   +1 more source

Fentanyl activates opposing opioid and non-opioid receptor systems that control breathing. [PDF]

Front Pharmacol
Baby SM, May WJ, Getsy PM, Coffee GA, Nakashe T, Bates JN, Levine A, Lewis SJ.   +7 more
europepmc   +1 more source