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The Journal of Steroid Biochemistry and Molecular Biology, 1994
The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
Siegfried Schwarz, Peter Pohl
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The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
Siegfried Schwarz, Peter Pohl
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Annual Review of Medicine, 2016
Opioids are the oldest and most potent drugs for the treatment of severe pain. Their clinical application is undisputed in acute (e.g., postoperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny. This article reviews mechanisms underlying opioid analgesia and other opioid actions.
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Opioids are the oldest and most potent drugs for the treatment of severe pain. Their clinical application is undisputed in acute (e.g., postoperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny. This article reviews mechanisms underlying opioid analgesia and other opioid actions.
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Opioid receptors and endogenous opioid peptides [PDF]
Medicinal Research Reviews, 1991 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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2003
There is little doubt that the use of opiates dates to early human history. There are references to opium in the Ebers Papyrus, and the ancient Sumerians recognized its euphoriant properties when they called the opium poppy the “plant of joy.” Despite millenia of compulsive use and abuse, the opiates are still unrivaled as analgesics, and derivatives ...
Gary J. Brenner, Jianren Mao, Carl Rosow
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There is little doubt that the use of opiates dates to early human history. There are references to opium in the Ebers Papyrus, and the ancient Sumerians recognized its euphoriant properties when they called the opium poppy the “plant of joy.” Despite millenia of compulsive use and abuse, the opiates are still unrivaled as analgesics, and derivatives ...
Gary J. Brenner, Jianren Mao, Carl Rosow
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Opioids, Receptors, and Immunity
1993The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune system, the extent and significance of ...
Martin W. Adler +4 more
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Fluorescent opioid receptor ligands as tools to study opioid receptor function
Journal of Pharmacological and Toxicological Methods, 2022Opioid receptors are divided into the three classical types: MOP(μ:mu), DOP(δ:delta) and KOP(κ:kappa) that are naloxone-sensitive and an additional naloxone-insensitive nociceptin/orphanin FQ(N/OFQ) peptide receptor(NOP). Studies to determine opioid receptor location and turnover variably rely on; (i) measuring receptor mRNA, (ii) genetically tagging ...
Giakomidi, Despina +4 more
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Opioid Peptides and their Receptors
1982The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz +2 more
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Regulation of Opioid Receptors by Their Endogenous Opioid Peptides
Cellular and Molecular Neurobiology, 2021Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the processing of three main precursors: proopiomelanocortin, proenkephalin, and prodynorphin.
Dinah L. Ramos-Ortolaza +11 more
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Opioids, opioid receptors, and the immune response
Drug and Alcohol Dependence, 2001It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human ...
Lois McCarthy +4 more
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Opioids and Opioid Receptors in Peripheral Tissues
Scandinavian Journal of Gastroenterology, 1987Opioid peptides belonging to the enkephalin, beta-endorphin or dynorphin family, acting on specific opiate receptors may be found in peripheral tissues. Enkephalins have a widespread peripheral distribution, while beta-endorphin and dynorphin may be found locally in the enteric nervous system.
Thomas Hedner, Jean Cassuto
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