Results 91 to 100 of about 15,125 (115)
Some of the next articles are maybe not open access.
Opioid mechanisms and opioid drugs
Anaesthesia & Intensive Care Medicine, 2019Abstract Opioids are effective in acute and cancer pain management and have increasingly been prescribed in chronic non-cancer pain despite concerns regarding long-term use and lack of efficacy. Opioid actions are via G protein coupled receptors, the activation of which leads to a variety of physiological consequences including analgesia. Prescribing
Helen Laycock, Carston Bantel
openaire +2 more sources
Opioid genetics in the context of opioid switching
Current Opinion in Supportive & Palliative Care, 2012On a population level, there is no difference in terms of efficacy or side-effects between any of the strong opioids. On an individual level, however, there is marked variation in response to opioids. This review presents some of the recent advances in opioid pharmacogenetic studies.A growing number of genes have been studied in a number of different ...
Joy Ross, Julia Riley, Joanne Droney
openaire +3 more sources
Opioid receptors and opioid pharmacodynamics
2005Abstract Opioids have a long and rich pharmacology. They are widely used throughout medicine and have been invaluable. However, they come with problems, including side effects such as constipation, respiratory depression and sedation, as well as the potential of abuse.
Mellar P Davis, Gavril W Pasternak
openaire +1 more source
Clinical Pharmacology & Therapeutics, 2007
Opioids are used for acute and chronic pain and dependency. They have a narrow therapeutic index and large interpatient variability in response. Genetic factors regulating their pharmacokinetics (metabolizing enzymes, transporters) and pharmacodynamics (receptors and signal transduction elements) are contributors to such variability.
Somogyi, A., Barratt, D., Coller, J.
openaire +4 more sources
Opioids are used for acute and chronic pain and dependency. They have a narrow therapeutic index and large interpatient variability in response. Genetic factors regulating their pharmacokinetics (metabolizing enzymes, transporters) and pharmacodynamics (receptors and signal transduction elements) are contributors to such variability.
Somogyi, A., Barratt, D., Coller, J.
openaire +4 more sources
2019
Despite many advances made in the field of interventional pain management in the past decades, pharmacological therapy often remains the core of the spine pain multimodal treatment. It represents an indispensable therapeutic tool, especially when more interventional methods either failed or are not indicated.
Yakov Vorobeychik +4 more
openaire +2 more sources
Despite many advances made in the field of interventional pain management in the past decades, pharmacological therapy often remains the core of the spine pain multimodal treatment. It represents an indispensable therapeutic tool, especially when more interventional methods either failed or are not indicated.
Yakov Vorobeychik +4 more
openaire +2 more sources
Journal of Pain & Palliative Care Pharmacotherapy, 2004
Opioid analgesics are an irreplaceable component of pharmacotherapy of numerous pain-producing conditions. Clinicians and patients must contend with the imperfect nature of this class of drugs, trying to balance benefits and burdens on a continual basis. New literature related to evidence-based selection of opioids and the neurobiological phenomenon of
openaire +2 more sources
Opioid analgesics are an irreplaceable component of pharmacotherapy of numerous pain-producing conditions. Clinicians and patients must contend with the imperfect nature of this class of drugs, trying to balance benefits and burdens on a continual basis. New literature related to evidence-based selection of opioids and the neurobiological phenomenon of
openaire +2 more sources
Opioid mechanisms and opioid drugs
Anaesthesia & Intensive Care Medicine, 2005Abstract Opioid analgesic drugs mimic the actions of three groups of endogenous opioid peptides, the enkephalins, dynorphins and endorphins. Opioid receptors have been cloned and have been classified as OP 1 (delta), OP 2 (kappa), OP 3 (mu) and OP 4 (ORL-1). The first three correspond to the classical opioid receptors that mediate analgesia.
openaire +2 more sources
Opioid Tolerance or Opioid Withdrawal?
Anesthesiology, 2013Sloan C. Youngblood, Mark J. Harbott
openaire +3 more sources