Results 131 to 140 of about 1,820 (184)

Opioids and Opioid Use Disorder in Pregnancy

Obstetrics and Gynecology Clinics of North America, 2023
Overdose is a leading cause of pregnancy-associated morbidity and mortality in the United States. As such, all obstetric providers have a responsibility to provide evidence-based care for patients with opioid use disorder to mitigate adverse outcomes associated with substance use during pregnancy.
Aalok R, Sanjanwala, Grace, Lim, Elizabeth E, Krans   +2 more
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Opioid and non-opioid analgesics

Best Practice & Research Clinical Anaesthesiology, 2003
Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Stephan A, Schug, William Robert, Garrett, Gail, Gillespie   +2 more
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Opioid Imaging

Neuroimaging Clinics of North America, 2006
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander, Lingford-Hughes, Anne   +1 more
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Opioid research in the time of the opioid crisis

British Journal of Pharmacology, 2023
LINKED ARTICLESThis article is part of a themed issue on Advances in Opioid Pharmacology at the Time of the Opioid Epidemic. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v180.7 ...
John R, Traynor, Jose A, Moron
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Opioids

Neurologic Clinics, 1993
The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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Opioid receptor polymorphismsand opioid abuse

Pharmacogenomics, 2002
The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
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Opioid and anti‐opioid peptides

Fundamental & Clinical Pharmacology, 1995
Summary— The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and the exogenous opioids (such as morphine) exert their effects through the activation of receptors belonging to four main types: μ, Δ, k and ε. Opioidergic neurones and opioid receptors are largely distributed centrally and peripherally. It is thus not surprising
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Non-opioid actions of opioid peptides

Life Sciences, 2004
Beside the well known actions of opioid peptides on mu-, delta- and kappa-opioid receptors, increasing amount of pharmacological and biochemical evidence has recently been published about non-opioid actions of various opioid peptides. These effects are not abolished by naloxone treatments.
Mária, Wollemann, Sándor, Benyhe
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‘Opioid’, opioids, pain, language and communication

Anaesthesia and Intensive Care, 2022
Over the last decades public discussion of opioids has changed radically. Opioid was once a word largely restricted to professional medical and pharmacological use for the treatment and management of pain. But propelled by the rapidly growing international wave of opioid use and overuse, it is now part of a much wider public discussion that covers more
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Opioid genetics in the context of opioid switching

Current Opinion in Supportive & Palliative Care, 2012
On a population level, there is no difference in terms of efficacy or side-effects between any of the strong opioids. On an individual level, however, there is marked variation in response to opioids. This review presents some of the recent advances in opioid pharmacogenetic studies.A growing number of genes have been studied in a number of different ...
Joanne, Droney, Julia, Riley, Joy, Ross
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