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Acompanhamento farmacoterapêutico de idosos em uso de analgésicos opioides em um hospital de ensino
, 2015 Heide De Sousa Silva Ribeiro +1 more
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Opioides: cómo usarlos en el dolor persistente sin morir en el intento
Actualización en Medicina de Familia, 2023Puntos clave El consumo de opioides en España se ha incrementado en los últimos años como consecuencia de su utilización en el dolor persistente no oncológico (DPNO). La evidencia científica muestra que su uso en este tipo de dolor es poco eficaz y tiene
Aina Perelló Bratescu +1 more
semanticscholar +1 more source
Surgical Neurology, 2007
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (
C, Zöllner, C, Stein
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Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (
C, Zöllner, C, Stein
openaire +4 more sources
Neuroimaging Clinics of North America, 2006
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
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Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
openaire +4 more sources
Opioid and non-opioid analgesics
Best Practice & Research Clinical Anaesthesiology, 2003Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Stephan A, Schug +2 more
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Neurologic Clinics, 1993
The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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Opioid receptor polymorphismsand opioid abuse
Pharmacogenomics, 2002The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
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, 2020
Nuestro objetivo es ejemplificar cómo el consumo de tóxicos y la comorbilidad con los trastornos mentales son factores de riesgo para el desarrollo de dependencia a opioides en pacientes tratados con analgésicos opioides.
Cándido Manuel García Sánchez +1 more
semanticscholar +1 more source
Nuestro objetivo es ejemplificar cómo el consumo de tóxicos y la comorbilidad con los trastornos mentales son factores de riesgo para el desarrollo de dependencia a opioides en pacientes tratados con analgésicos opioides.
Cándido Manuel García Sánchez +1 more
semanticscholar +1 more source
Opioid and anti‐opioid peptides
Fundamental & Clinical Pharmacology, 1995Summary— The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and the exogenous opioids (such as morphine) exert their effects through the activation of receptors belonging to four main types: μ, Δ, k and ε. Opioidergic neurones and opioid receptors are largely distributed centrally and peripherally. It is thus not surprising
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