Results 71 to 80 of about 15,125 (115)

Opioids

Surgical Neurology, 2007
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (
C, Zöllner, C, Stein
openaire   +4 more sources

Opioid mechanisms and opioid drugs

Anaesthesia & Intensive Care Medicine, 2008
Abstract The opioid system comprises four receptor subtypes: μ (MOP), κ (KOP), δ (DOP) (i.e. the so-called ‘classical' opioid receptors) and the more recently identified nociceptin/orphanin FQ peptide (N/OFQ) receptor (NOP). Selective endogenous peptides, typically cleaved from larger precursor proteins, have been identified for all subtypes.
McDonald, J, Lambert, DG
openaire   +4 more sources

Opioid and non-opioid analgesics

Best Practice & Research Clinical Anaesthesiology, 2003
Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Gail Gillespie   +2 more
openaire   +3 more sources

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