Results 81 to 90 of about 15,125 (115)
Opioid receptor polymorphismsand opioid abuse [PDF]
Pharmacogenomics, 2002 The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Andrew P. Smith, Nancy M. Lee
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Neuroimaging Clinics of North America, 2006
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
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Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
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New England Journal of Medicine, 2011
To the Editor: We applaud the article by Okie (Nov. 18 issue)1 on the increasing number of overdose deaths, since we have seen far too many patients die prematurely of opioid overdoses. One topic was missing from this article: the usefulness of providing access to naloxone to be administered by laypersons to prevent death from an opioid overdose ...
Michelle McKenzie +2 more
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To the Editor: We applaud the article by Okie (Nov. 18 issue)1 on the increasing number of overdose deaths, since we have seen far too many patients die prematurely of opioid overdoses. One topic was missing from this article: the usefulness of providing access to naloxone to be administered by laypersons to prevent death from an opioid overdose ...
Michelle McKenzie +2 more
openaire +7 more sources
Opioid and anti‐opioid peptides
Fundamental & Clinical Pharmacology, 1995Summary— The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and the exogenous opioids (such as morphine) exert their effects through the activation of receptors belonging to four main types: μ, Δ, k and ε. Opioidergic neurones and opioid receptors are largely distributed centrally and peripherally. It is thus not surprising
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Neurologic Clinics, 1993
The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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Non-opioid actions of opioid peptides
Life Sciences, 2004Beside the well known actions of opioid peptides on mu-, delta- and kappa-opioid receptors, increasing amount of pharmacological and biochemical evidence has recently been published about non-opioid actions of various opioid peptides. These effects are not abolished by naloxone treatments.
Maria Wollemann, Sándor Benyhe
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Opioid receptors and endogenous opioid peptides [PDF]
Medicinal Research Reviews, 1991 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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1984
Publisher Summary Opioid peptides are endogenous or synthetic peptides characterized by a spectrum of pharmacological activity similar to that of morphine and other narcotic agonist drugs. This chapter describes the psychobiology of opiates by analyzing their neurochemical correlates at the brain level and the role of different receptor sites.
OLIVERIO, Alberto +2 more
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Publisher Summary Opioid peptides are endogenous or synthetic peptides characterized by a spectrum of pharmacological activity similar to that of morphine and other narcotic agonist drugs. This chapter describes the psychobiology of opiates by analyzing their neurochemical correlates at the brain level and the role of different receptor sites.
OLIVERIO, Alberto +2 more
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Opioids, opioid receptors, and the immune response
Drug and Alcohol Dependence, 2001It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human ...
Lois McCarthy +4 more
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Opioids and Opioid Receptors in Peripheral Tissues
Scandinavian Journal of Gastroenterology, 1987Opioid peptides belonging to the enkephalin, beta-endorphin or dynorphin family, acting on specific opiate receptors may be found in peripheral tissues. Enkephalins have a widespread peripheral distribution, while beta-endorphin and dynorphin may be found locally in the enteric nervous system.
Thomas Hedner, Jean Cassuto
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