Results 81 to 90 of about 41,014 (318)

Improved predictions of nonlinear support vector regression and artificial neural network models via preprocessing of data with orthogonal projection to latent structures: A case study

Bulletin of Faculty of Pharmacy Cairo University, 2017
In the presented study, orthogonal projection to latent structures (OPLS) is introduced as a data preprocessing method that handles nonlinear data prior to modelling with two well established nonlinear multivariate models; namely support vector ...
Ibrahim A. Naguib
doaj  

Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions

JCI Insight, 2021
BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the most frequently dysregulated signaling events in head and neck squamous cell carcinoma (HNSCC).
J. Silvio Gutkind, Alfredo A. Molinolo, Xingyu Wu, Zhiyong Wang, Daniela Nachmanson, Olivier Harismendy, Ludmil B. Alexandrov, Beverly R. Wuertz, Frank G. Ondrey, Denise Laronde, Leigha D. Rock, Miriam Rosin, Charles Coffey, Valerie D. Butler, Lisa Bengtson, Chiu-Hsieh Hsu, Julie E. Bauman, Stephen M. Hewitt, Ezra E.W. Cohen, H-H. Sherry Chow, Scott M. Lippman, Eva Szabo   +21 more
doaj   +1 more source

Gender discrimination of Populus tomentosa barks by HPLC fingerprint combined with multivariate statistics

Plant Direct, 2021
A high‐performance liquid chromatography (HPLC) fingerprint method with multivariate statistical analyses was applied to discriminate the male and female barks of Populus tomentosa for the first time.
Cui Wu, Bo Xu, Zhuojun Li, Pingping Song, Zhimao Chao   +4 more
doaj   +1 more source

Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. [PDF]

, 2017
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy ...
Erle, David J, Heyder, Tina, Kamleh, Muhammad Anas, Kolmert, Johan, Levänen, Bettina, Naz, Shama, Reinke, Stacey N, Sköld, C Magnus, Snowden, Stuart, Wheelock, Craig E, Wheelock, Åsa M, Yang, Mingxing   +11 more
core   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Secondary-Structure Design of Proteins by a Backbone Torsion Energy [PDF]

, 2005
We propose a new backbone-torsion-energy term in the force field for protein systems. This torsion-energy term is represented by a double Fourier series in two variables, the backbone dihedral angles phi and psi.
Berendsen H. J. C., Blanco F. J., Cornell W. D., Duan Y., Garcia A. E., Honda S., Iwaoka M., Jorgensen W. L., Kabsch W., Kaminski G. A., Kamiya N., Kirkpatrick S., Kobayashi N., Kraulis P. J., MacKerell A. D., MacKerrell A. D., Merritt E. A., Mitsutake A., Némethy G., Osterhout J. J., Qiu D., Ramachandran G. N., Sakae Y., Sakae Y., Sakae Y., Shoemaker K. R., Simmerling C., Still W. C., Wang J., Yoda T., Yoda T.   +30 more
core   +2 more sources

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Soft-sensor model development for CHO growth/production, intracellular metabolite, and glycan predictions

Frontiers in Molecular Biosciences
Efficaciously assessing product quality remains time- and resource-intensive. Online Process Analytical Technologies (PATs), encompassing real-time monitoring tools and soft-sensor models, are indispensable for understanding process effects and real-time
George Liang, Sha Sha, Zhao Wang, Huolong Liu, Seongkyu Yoon   +4 more
doaj   +1 more source

Getting excited: Challenges in quantum-classical studies of excitons in polymeric systems [PDF]

, 2016
A combination of classical molecular dynamics (MM/MD) and quantum chemical calculations based on the density functional theory (DFT) was performed to describe conformational properties of diphenylethyne (DPE), methylated-DPE and poly para phenylene ...
Bagheri, Behnaz, Baumeier, Björn, Karttunen, Mikko   +2 more
core   +4 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source