Results 81 to 90 of about 59,185 (218)
Abstract Prestin, a member of the SLC26A family, is essential for the electromotility of mammalian outer hair cells, converting voltage changes into mechanical work. In contrast, nonmammalian orthologues function as anion transporters. To investigate the molecular and structural basis of this functional divergence, we performed ancestral sequence ...
Nicolás Fuentes‐Ugarte +6 more
wiley +1 more source
MAVISp: A modular structure‐based framework for protein variant effects
Abstract The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and ...
Matteo Arnaudi +32 more
wiley +1 more source
Topological classification of vortex-core structures of spin-1 Bose-Einstein condensates
We classify vortex-core structures according to the topology of the order parameter space. By developing a method to characterize how the order parameter changes inside the vortex core.
G. E. Volovik +8 more
core +1 more source
A Bibliometric Review of the INCOSE's Model‐Based Systems Engineering Roadmap
ABSTRACT Over the past decade, model‐based systems engineering (MBSE) has gained attention as an approach for managing system complexity, offering a shift from a document‐based to a model‐based approach. The International Council on Systems Engineering (INCOSE) sparked increasing interest when it introduced MBSE and its roadmap as part of its systems ...
Marjolein Antoinette Jannyne Velthuizen +2 more
wiley +1 more source
Operator projection method applied to the single-particle Green's function in the Hubbard model
A new non-perturbative framework for many-body correlated systems is formulated by extending the operator projection method (OPM). This method offers a systematic expansion which enables us to project into the low-energy structure after extracting the ...
Assaad F. F. +23 more
core +1 more source
A Unified Requirements‐Architecture System Model—Development and Empirical Evaluation
ABSTRACT Moving systems engineering's center of gravity from text documents to digital models, model‐based system engineering (MBSE) facilitates collaboration, reduces errors, and improves system understanding, but systems engineers often face challenges when they start working with MBSE, as they need to consider and model textual requirements as a ...
Liat Katzir +2 more
wiley +1 more source
Precision medicine is a term describing strategies to promote health and prevent and treat disease based on an individual’s genetic, molecular, and lifestyle characteristics.
Michael A. Thompson +10 more
doaj +1 more source
Federal Employees: Human Resources Management Flexibilities in Emergency Situations [PDF]
[Excerpt] Federal executive branch departments and agencies have available to them various human resources management flexibilities which can be utilized in emergency situations, such as those which resulted from Hurricanes Katrina and Rita and which ...
Schwemle, Barbara L
core +1 more source
Abstract One promising potential site for extracting supercritical geothermal fluids is the Krafla volcano, Iceland, into which a borehole was drilled very close to a shallow rhyolite magma chamber at about 2 km depth. Besides the technical challenge to drill in this setting, the extreme temperature conditions of T > 900°C close to the magma body may ...
E. Rybacki +3 more
wiley +1 more source
Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh Operating Profit Margin (OPM) dan Net Profit Margin (NPM) terhadap harga saham. Penelitian ini menggunakan dua variabel independen yang terdiri dari Operating Profit Margin (OPM) dan Net Profit ...
Ulfa Dhia Musyafa Arlin Ferlina Moch
doaj +1 more source

