Results 101 to 110 of about 6,156,970 (335)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Conference Report The 16th Asia Europe Economic Forum. EU-Asia trade and investment connectivity [PDF]

open access: yes, 2020
Global economic trends over the last decades have steadily increased the links between Asia and Europe. For both regions, a growing economic interdependency represents an opportunity to build strong, fair and sustainable relations.
Coka, Daniela Arregui, Jungbluth, Cora
core  

Tracking the built status of MEP works: Assessing the value of a Scan-vs-BIM system [PDF]

open access: yes, 2014
Mechanical, electrical, and plumbing (MEP) works constitute a large portion of construction costs and thus need to be appropriately tracked. Assessment of the built status of MEP works in construction projects is however typically limited to ...
Bosché, Frédéric   +4 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

TECHNOLOGICAL INNOVATION ACTIVITIES IN FIRMS AND PROPENSITY OF INDIVIDUALS STARTING NEW BUSINESSES [PDF]

open access: yes
Prior studies have found that knowledge gained from work experience is a way to gather insights for business opportunity recognition. However, little is known about the specific types of knowledge that lead to business founding.
Foo, Maw Der, Lee, Lena, Wong, Poh Kam
core   +1 more source

FACTS MODEL UNTUK PEMBINAAN MOTIVASI BAGI PENINGKATAN KINERJA KARYAWAN (Studi Kasus Motivasi pada Badan Usaha Jasa Penerbangan Internasional di Surabaya) [PDF]

open access: yes, 2002
A conceptual argumentations on basic motivation for workers in repetitive tasks usually known and picture as a constan curve. All efforts to increase employee's motivation find the successful whenever management enable to create a specific program such ...
Rusdiyanto, Johny
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Opportunities & Challenges In Automatic Speech Recognition

open access: yes, 2013
Automatic speech recognition enables a wide range of current and emerging applications such as automatic transcription, multimedia content analysis, and natural human-computer interfaces. This paper provides a glimpse of the opportunities and challenges that parallelism provides for automatic speech recognition and related application research from the
Makhijani, Rashmi   +2 more
openaire   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Does the Introduction of IFRS Change the Timeliness of Loss Recognition? Evidence from German Firms [PDF]

open access: yes
In this paper, we re-evaluate the hypothesis that the introduction of the IFRS has an impact on the timeliness of loss recognition. We test this hypothesis in a data set of public German firms that report according to German-GAAP and IFRS, respectively ...
Carl-Friedrich Leuschner   +2 more
core  

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