Results 61 to 70 of about 119,554 (269)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Tempo di inquietudini. La segreteria Natta raccontata da L’Unità (1984-1989)
The paper aims to describe the years of Alessandro Natta as Secretary of the Italian Communist Party from 1985 to 1988. It reconstructs the self-representation of the party’s leadership through its newspaper.
Michelangela Di Giacomo si è addottorata presso l’Università di Siena; è Borsista presso l’Institut d’Estudis Catalans di Barcellona e Cultore della materia presso il Dispi-Università di Siena. Ha vinto con le sue tesi il premio della Presidenza della Repubblica/Fondazione Spadolini nel 2012 e di quello del Senato della Repubblica nel 2009.
doaj
Latin America: Presidential Power and the Opposition in the Twenty-first Century
At the end of 2017 Latin America has entered the electoral super cycle, which runs until the end of 2019. In the region will take place the elections of all levels: presidential, legislative, local, as well as referendums.
N. M. YAKOVLEVA
doaj +1 more source
Cognition is affected by psychophysiological states. While the influence of stress on cognition has been investigated intensively, less studies have addressed how the opposite of stress, a state of relaxation, affects cognition. We investigated whether the extent of parasympathetic activation is positively related to divergent thinking.
Meier, Maria +8 more
openaire +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
After carrying out some general considerations on protected geographical denominations, the paper approaches the analysis of the causes of opposition to the application of administrative recognition foreseen by the community normative. It is an extremely
Ángel Martínez Gutiérrez
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Novel Rahuvana Tattwa digunakan dalam penelitian ini untuk mengkaji teori intertekstual perspektif Julia Kristeva yang berupa oposisi. Terdapat dua pertentangan atau lebih yang disandingkan dalam teori oposisi.
Viandika Indah Septiyani +1 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source

