Results 101 to 110 of about 67,593 (295)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Dominant Optic Atrophy and Sensorineural Hearing-loss

open access: yes, 1991
The authors report three patients belonging to three generations of the same family presenting with a dominant optic atrophy; two of these patients (grandfather, mother) also suffered from a mild hearing loss.
Waterschoot, MP.   +3 more
core   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Aetiological Profile of Optic Atrophy: A hospital based prospective study

open access: yes, 2020
Objectives: This study was to evaluateclinical presentations and aetiological profiles of patients with optic atrophy.Methods:The patients had undergone complete ophthalmological examination, i.e.
Agrawal, Shilpi   +5 more
core  

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

open access: yesArthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk   +7 more
wiley   +1 more source

Segmental Atrophy - Hemianopic (Band) Atrophy from Eight Optic Tract Injury

open access: yes
Segmental Atrophy - Band atrophy from right optic tract injury. Left eye. Has temporal hemianopia with band atrophy. Note loss of nasal nerve fiber layer. Four and a half months after injury from intracranial pressure catheter.
William F. Hoyt, MD
core   +1 more source

Optic Coherence Tomography in Patients with Dominant Optic Atrophy

open access: yes, 2007
In dominant optic atrophy (DOA), the few available histopathologic reports appear to demonstrate selective loss of retinal ganglion cells with ascending optic atrophy, the loss being most pronounced in the macular area and retinal nerve fiber loss most ...
Dan Milea; Birgit Sander; Marianne Wegener; Hanne Jensen; Birgit Kjer; Henrik Lund-Andersen; Michael Larsen
core  

Carboxylic‐Acid Functionalized Multiwalled Carbon Nanotube‐Alkane‐Based Resistive Temperature Sensor for Cold Chain Applications

open access: yesAdvanced Engineering Materials, EarlyView.
This study presents a reversible temperature sensor with high switching ratio, ∼103. The device is fabricated using PET‐ITO and carbon nanotube dispersions in alkane. Considering its application in cold chain logistics, a proof‐of‐concept with LED is showcased. Thus, a temperature drop below the threshold temperature (crystallization temperature of the
Sunil Kumar Behera   +8 more
wiley   +1 more source

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