Results 61 to 70 of about 347,881 (287)

From Diagnosis to Disease Staging: Multisite Validation of Cerebrospinal Fluid Molecular Tests in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The growing demand for personalized treatment in multiple sclerosis (MS) highlights the need for more precise biomarkers that can outperform magnetic resonance imaging and clinical assessment in patient stratification. Advances in multiplex proteomic technologies suggest that cerebrospinal fluid (CSF) analysis at MS onset may not only improve
Laura Ghezzi, Peter Kosa, Mark Greenwood, Enrique Alvarez, C.L. Freedman, Anne H. Cross, Francesca Pace, Mark S. Freedman, Joanna Kocot, Laura Piccio, Bibiana Bielekova   +10 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Mid‐Regional Proadrenomedullin in Cerebrospinal Fluid Is a Reliable Diagnostic and Prognostic Marker for Acute Meningoencephalitis and Neurological Disorders

Journal of Clinical Laboratory Analysis, EarlyView.
MR‐ProADM levels reflect Adrenomedullin response to BBB damage. CSF levels are quite variable across different neurological syndromes, but they are particularly high in acute CNS infections, which makes MR‐ProADM a promising additional diagnostic and prognostic biomarker in this setting.
Francesco Janes, Paola Dalla Siega, Marco Comar, Matteo Furlani, Agnese Zanus Fortes, Daniela Visentini, Andrea Ripoli, Francesco Sbrana, Novella Carannante, Silvia Leonardi, Francesco Curcio, Mariarosaria Valente, Martina Fabris, Carlo Tascini   +13 more
wiley   +1 more source

Current options for the treatment of optic neuritis

Clinical Ophthalmology, 2012
John H Pula,1 Christopher J MacDonald21Division of Neuro-ophthalmology, University of Illinois College of Medicine at Peoria, Peoria; 2University of Illinois College of Medicine at Urbana-Champaign, Champaign, IL, USAAbstract: Optic neuritis can be ...
Pula JH, MacDonald CJ
doaj  

Anxiety and Depression in Adults With Vestibular Disorders: A Systematic Review and Meta‐Analysis

The Laryngoscope, EarlyView.
This systematic review and meta‐analysis of 85 studies (n = 764,403) found that adults with vestibular disorders have markedly higher rates and risks of anxiety and depression than controls. Prevalence was greatest in episodic conditions such as vestibular migraine and Ménière's disease.
Cory Hyun‐su Kim, Lauren R. McCray, Shaun A. Nguyen, Jeffrey P. Staab, Shabih Jafri, Habib Rizk   +5 more
wiley   +1 more source

The clinical profile of new-onset optic neuritis in arabs, a tertiary center experience in Kuwait

Heliyon
Background: Optic neuritis is an inflammatory disorder of the optic nerve and is often the initial manifestation of systemic demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optic spectrum disorder (NMOSD), and myelin-oligodendrocyte
Raed Behbehani, Abdullah Ali, Ahmed Alakool, Samar Farouk, Raed Alroughani   +4 more
doaj   +1 more source

A rare case of bilateral optic neuritis post-Covishield (ChAdOx1-S [recombinant]) vaccination

Oman Journal of Ophthalmology, 2023
Multiple adverse effects have been reported in people receiving the COVID-19 vaccinations including few reports of optic neuritis. However, there is no report till date, of bilateral optic neuritis post-ChAdOx1-S (recombinant) vaccination. We report here,
Tanie Natung, Thangjam Amit Singh, Oinam Somapika Devi, Ishita Pandey   +3 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

The pathogenesis of optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice

Parasites & Vectors, 2014
Background One of the most common causes of meningitis in South East Asia is angiostrongyliasis or infection by the parasitic nematode Angiostrongyliasis cantonensis.
Ying Feng, Xin Zeng, Wei-Hua Li, Wen-Cong Wang, Wei Chen, Li-si Ou-Yang, Xi Sun, Feng Feng, Zhong-Dao Wu   +8 more
doaj   +1 more source

Does time equal vision in the acute treatment of a cohort of AQP4 and MOG optic neuritis?

Neurology: Neuroimmunology & Neuroinflammation, 2019
Objective To investigate whether visual disability which is known to accumulate by poor recovery from optic neuritis (ON) attacks can be lessened by early treatment, we investigated whether the time from symptom onset to high-dose IV methylprednisolone ...
H. Stiebel-Kalish, M. Hellmann, M. Mimouni, F. Paul, O. Bialer, Michael Bach, I. Lotan   +6 more
semanticscholar   +1 more source