Results 61 to 70 of about 43,716 (252)

Hyperreflective Foci in the Inner Nuclear Layer: Proof‐of‐Concept for an Optical Coherence Tomography Derived Microglia‐Related Marker in Multiple Sclerosis

Annals of Neurology, EarlyView.
The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical coherence tomography (OCT) within the inner nuclear layer (INL) of the retina, can be used as a marker for microglial ...
Jonathan A. Gernert, Laura M. Bartos, Tara Christmann, Hanna Zausinger, Luca N. Diedrich, Daniel Engels, Miriam Schlüter, Sarah Schlaeger, Sophia Stoecklein, Leonie F. Keidel, Tania Kümpfel, Martin Kerschensteiner, Matthias Brendel, Joachim Havla   +13 more
wiley   +1 more source

The clinical profile of new-onset optic neuritis in arabs, a tertiary center experience in Kuwait

Heliyon
Background: Optic neuritis is an inflammatory disorder of the optic nerve and is often the initial manifestation of systemic demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optic spectrum disorder (NMOSD), and myelin-oligodendrocyte
Raed Behbehani, Abdullah Ali, Ahmed Alakool, Samar Farouk, Raed Alroughani   +4 more
doaj   +1 more source

Tranexamic Acid Use in Hip Arthroscopy Reduces Bleeding Without Increased Risk of Major Complications: A Systematic Review

Arthroscopy, EarlyView.
Purpose To critically evaluate the impact of tranexamic acid (TXA) on hip arthroscopy outcomes, including its effects on bleeding, functional recovery, postoperative pain, complications, intraoperative visualization, and surgical efficiency. Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic ...
Paul B. Walker, Mathangi Sridharan, Adrian Lin, Atousa Nourmahnad, Alexander Fish, Sharon L. Hame, Kristofer J. Jones   +6 more
wiley   +1 more source

A rare case of bilateral optic neuritis post-Covishield (ChAdOx1-S [recombinant]) vaccination

Oman Journal of Ophthalmology, 2023
Multiple adverse effects have been reported in people receiving the COVID-19 vaccinations including few reports of optic neuritis. However, there is no report till date, of bilateral optic neuritis post-ChAdOx1-S (recombinant) vaccination. We report here,
Tanie Natung, Thangjam Amit Singh, Oinam Somapika Devi, Ishita Pandey   +3 more
doaj   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

A Novel Slit Lamp‐Based System for 3D Ultrasound of the Eye

Journal of Ultrasound in Medicine, EarlyView.
Objectives This study aims to develop and evaluate a novel slit‐lamp‐based system to acquire 3‐dimensional (3D) ultrasound volumes using conventional ultrasound probes. Methods A slit‐lamp adapter was 3D printed and connected with a linear actuator and graphical user interface (GUI) system to control movement and create volumes of 2‐dimensional scans ...
Claire E. Malley, Joseph P. Miller, Boyan Pan, Josiah K. To, Jack O. Thomas, Steven Y. Chang, Jason Dagoon, William C. Tang, Parsa Riazi Esfahani, Andrew W. Browne   +9 more
wiley   +1 more source

The pathogenesis of optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice

Parasites & Vectors, 2014
Background One of the most common causes of meningitis in South East Asia is angiostrongyliasis or infection by the parasitic nematode Angiostrongyliasis cantonensis.
Ying Feng, Xin Zeng, Wei-Hua Li, Wen-Cong Wang, Wei Chen, Li-si Ou-Yang, Xi Sun, Feng Feng, Zhong-Dao Wu   +8 more
doaj   +1 more source

Rodent Models of Optic Neuritis

Frontiers in Neurology, 2020
Optic neuritis (ON) is an inflammatory attack of the optic nerve that leads to visual disability. It is the most common optic neuropathy affecting healthy young adults, most commonly women aged 20–45 years.
Yael Redler, Michael Levy
doaj   +1 more source

Hyperacute optic neuritis in a patient with COVID-19 infection and vaccination: a case report

BMC Ophthalmology, 2023
Background As scientific knowledge continues to grow regarding coronavirus disease 2019 (COVID-19) infection, several neuro-ophthalmological manifestations have emerged, including rare reports of optic neuritis.
Jessica Zhang, Devon Joiner, Cheng Zhang
doaj   +1 more source