Results 91 to 100 of about 2,756,584 (366)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Freeform Surface Graded Optimization of Deformable Mirrors in Integrated Zoom and Image Stabilization System Through Vectorial Ray Tracing and Image Point Freezing Method

IEEE Photonics Journal, 2020
Integrated zoom and image stabilization system based on deformable mirrors (DMs) has advantages of miniaturization, rapid response and low energy consumption.
Yan Ning, Yao Hu, Xuemin Cheng, Qun Hao, Yang Cheng, Tengfei Li, Xin Tao   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Recent Progress on Ultrathin Metalenses for Flat Optics

iScience, 2020
Summary: As technology advances, electrical devices such as smartphones have become more and more compact, leading to a demand for the continuous miniaturization of optical components.
Seong-Won Moon, Yeseul Kim, Gwanho Yoon, Junsuk Rho   +3 more
doaj   +1 more source

Adaptive optical microscopy via virtual-imaging-assisted wavefront sensing for high-resolution tissue imaging

PhotoniX, 2022
Adaptive optics (AO) is a powerful tool for optical microscopy to counteract the effects of optical aberrations and improve the imaging performance in biological tissues.
Zhou Zhou, Jiangfeng Huang, Xiang Li, Xiujuan Gao, Zhongyun Chen, Zhenfei Jiao, Zhihong Zhang, Qingming Luo, Ling Fu   +8 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

exCTF simulator: Simulation tool for phase contrast transfer function for aberration-corrected transmission electron microscopy

Journal of Analytical Science and Technology, 2020
Background The contrast transfer function (CTF) is an important principle in the field of transmission electron microscopy (TEM) imaging. It provides information on how the electron wave that interacted with a sample (in frequency domain) in an objective
Sang-Chul Lee, Jong-Man Jeung, Sang-Gil Lee, Jin-Gyu Kim   +3 more
doaj   +1 more source

Topology Optimized Multi-layered Meta-optics

, 2017
We propose a general topology optimization framework for metasurface inverse design that can automatically discover highly complex multi-layered meta-structures with increased functionalities.
Capasso, Federico, Groever, Benedikt, Lin, Zin, Lončar, Marko, Rodriguez, Alejandro W.   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cascaded metasurfaces enabling adaptive aberration corrections for focus scanning

Opto-Electronic Advances
Scanning focused light with corrected aberrations holds great importance in high-precision optical systems. However, conventional optical systems, relying on additional dynamical correctors to eliminate scanning aberrations, inevitably result in ...
Xiaotong Li, Xiaodong Cai, Chang Liu, Yeseul Kim, Trevon Badloe, Huanhuan Liu, J. Rho, Shiyi Xiao   +7 more
semanticscholar   +1 more source