Results 11 to 20 of about 60,016 (245)

Coupled experiment/simulation approach for the design of radiation-hardened rare-earth doped optical fibers and amplifiers [PDF]

, 2011
We developed an approach to design radiation-hardened rare earth -doped fibers and amplifiers. This methodology combines testing experiments on these devices with particle swarm optimization (PSO) calculations.
F. Prudenzano, Mescia, L, Vivona, M., Girard, S, Boukenter, Aziz, A. Boukenter, Goiffon, V, Cannas, M., V. Goiffon, Mescia, Luciano, Boukenter, A, L. Mescia, Vivona, Marilena, Mescia, L., R. Boscaino, Cadier, B., P. Paillet, Paillet, P., Y. Ouerdane, Boukenter, A., Paillet, P, Paillet, Philippe, Marcandella, C, Cadier, Benoît, S. Girard, A. Laurent, Laurent, A, Robin, T, C. Marcandella, Goiffon, Vincent, Cadier, B, Ouerdane, Y., Ouerdane, Y, Girard, Sylvain, Prudenzano F, Robin, Thierry, F. Robin, Prudenzano, F, Laurent, Arnaud, Boscaino, Roberto, T. Robin, Robin, T., B. Cadier, Marcandella, C., Goiffon, V., Cannas, Marco, M. Cannas, Prudenzano, F., Boscaino, R., Prudenzano, Francesco, Ouerdane, Youcef, M. Vivona, Girard, Sébastien, Marcandella, Claude, Laurent, A.   +54 more
core   +1 more source

Asymmetric optical loop mirror : analysis of an all-optical switch [PDF]

, 1994
A general analytical framework for tetrahertz optical asymmetric demultiplexer (TOAD) switch operation is presented and compared with other switches that use a nonlinear optical element in a loop mirror.
Glesk, Ivan, Prucnal, Paul R., Kane, Michael G., Sokoloff, Jason P.   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Optical High-Capacity Satellite Downlinks via High-Altitude Platform Relays

, 2007
Earth-observation (EO) satellite missions produce a large amount of data using high-resolution optical or radar sensors. During the last decades the amount of data has steadily increased due to improved sensor technologies with increased temporal ...
Florian Moll, Bischl, Hermann, Markus Knapek, Giggenbach, Dirk, Joachim Horwath, Horwath, Joachim, Courville, Nicolas, Knapek, Markus, Bernd Epple, Moll, Florian, Nicolas Courville, Hermann Bischl, Epple, Bernhard, Dirk Giggenbach   +13 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

An optical threshold function based on polarization rotation in a single semiconductor optical amplifier [PDF]

, 2007
Optical threshold functions are a basic building block for alloptical signal processing, and this paper investigates a threshold function design reliant on a single active element. An optical threshold function based on nonlinear polarization rotation in
Liu, Y Yong, Vegas Olmos, J.J., Geldenhuys, R., Leuschner, F.W., Leuschner, FW, Khoe, GD Giok-Djan, Liu, Y., Khoe, G.D., Dorren, HJS Harm, Vegas Olmos, JJ Juan José, Dorren, H.J.S., Geldenhuys, R   +11 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source