Results 51 to 60 of about 2,321,906 (295)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Investigation of in-situ parameter control in novel semiconductor optical amplifiers [PDF]

, 2012
Fibre optic networks form the backbone of modern communications systems. As demand for ever increasing bandwidth continues to grow, technologies that enable the expansion of optical networks will be the key to future development.
Carney, Kevin
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Optical Fiber Amplifiers: Optimization and PerformanceEvaluation

Diyala Journal of Engineering Sciences, 2019
This work demonstrates the simulation of two different types of optical fiber amplifiers (OFA) utilizing OptiSystem–10, namely, 3 m length of erbium doped fiber amplifier (EDFA) and 7 km length of Raman fiber amplifier (RFA).
A. k. Abass, Mohammed J. Abdul-Razak, Haneen H. Mohammed, Suad M. Kadhim, Mohammed A. Salih   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Amplifying characteristics Er-doped chalcogenide glass [PDF]

Hemijska Industrija, 2010
The paper presents the measurement results of optical amplifying characteristics of Er-doped As-S-Ge chalcogenide glasses. The measurements included the amplification of useful laser source power during propagation along two axes of samples.
Petrović Vesna, Stojanović Nikola, Slankamenac Miloš P., Lukić Svetlana R.   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

An optical threshold function based on polarization rotation in a single semiconductor optical amplifier [PDF]

, 2007
Optical threshold functions are a basic building block for alloptical signal processing, and this paper investigates a threshold function design reliant on a single active element. An optical threshold function based on nonlinear polarization rotation in
Liu, Y Yong, Vegas Olmos, J.J., Geldenhuys, R., Leuschner, F.W., Leuschner, FW, Khoe, GD Giok-Djan, Liu, Y., Khoe, G.D., Dorren, HJS Harm, Vegas Olmos, JJ Juan José, Dorren, H.J.S., Geldenhuys, R   +11 more
core   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Impact of signal wavelength on the semiconductor opticalamplifier gain uniformity for high speed optical routers employing the segmentation model [PDF]

, 2010
This paper investigates the impact of a train of input Gaussian pulses wavelength on semiconductor optical amplifier (SOA) gain uniformity for high speed applications. In high speed applications, the linear output gain of the input pulses is necessary in
Ghassemlooy, Zabih, Ng, Wai Pang, A. Abd El A, R. Ngah, Z. Ghassemlooy, M. H. Aly, Aly, Moustafa, M. F. Chiang, Chiang, Ming-Feng, Ngah, Razali, W. P. Ng, Abd El Aziz, Ahmad   +11 more
core   +1 more source