Results 211 to 220 of about 35,239 (296)

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh   +5 more
wiley   +1 more source

A Quasi-Resonant System for High-Frequency Trans-Spinal Magnetic Stimulation (HF-TSMS). [PDF]

open access: yesIEEE Trans Biomed Eng
Marturano F   +5 more
europepmc   +1 more source

Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy

open access: yesCancer Science, EarlyView.
Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen   +9 more
wiley   +1 more source

Splatshop: Efficiently Editing Large Gaussian Splat Models

open access: yesComputer Graphics Forum, EarlyView.
Abstract We present Splatshop, a highly optimized toolbox for interactive editing (selection, deletion, painting, transformation, …) of 3D Gaussian Splatting models. Utilizing a comprehensive collection of heuristic approaches, we carefully balance between exact and fast rendering to enable precise editing without sacrificing real‐time performance. Our
Markus Schütz   +5 more
wiley   +1 more source

Design Considerations for Visualization Transitions of 3D Spatial Data in Hybrid AR‐Desktop Environments

open access: yesComputer Graphics Forum, EarlyView.
We present design considerations for animated transitions of the appearance of 3D spatial datasets in a hybrid Augmented Reality‐desktop context. Such hybrid interfaces combine both traditional and immersive displays to facilitate the exploration of 2D and 3D data representations in the environment in which they are best displayed.
Yucheng Lu   +6 more
wiley   +1 more source

Stability analysis of single-wavelength optical buffers [PDF]

open access: yes, 2009
Bruneel, Herwig   +4 more
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