Results 101 to 110 of about 2,013 (228)

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li   +8 more
wiley   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

open access: yesMedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan   +17 more
wiley   +1 more source

CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1‐Dependent RAS/MAPK Activation

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
The mechanism by which CSDE1 promotes prostate cancer progression through RAC1‐dependent RAS/MAPK activation and enhanced glycolysis. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related morbidity and mortality among men, necessitating the elucidation of molecular drivers behind its progression.
Zhen Yin   +12 more
wiley   +1 more source

Optimization of spray‐drying conditions for green acerola concentrate juice: effect of temperature and maltodextrin

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2527-2541, 15 March 2026.
Abstract BACKGROUND Acerola (Malpighia glabra and M. emarginata) is a tropical fruit predominantly cultivated in northeastern Brazil, notable for its abundance of health‐beneficial bioactive compounds, including ascorbic acid, phenolic compounds, flavonoids, and anthocyanins.
Fábia Sabino Costa   +7 more
wiley   +1 more source

Multimodal AI teacher: Integrating edge computing and reasoning models for enhanced student error analysis

open access: yesAI Magazine, Volume 47, Issue 1, Spring 2026.
Abstract Students frequently make mistakes while solving mathematical problems, and traditional error correction methods are both time‐consuming and labor‐intensive. This paper introduces an innovative Virtual AI Teacher system (VATE) designed to autonomously analyze and correct student Errors.
Tianlong Xu   +3 more
wiley   +1 more source

An actionable framework for AI‐ready data

open access: yesAI Magazine, Volume 47, Issue 1, Spring 2026.
Abstract Data is the foundation of AI. Poor‐quality data drive up costs and can lead to hidden problems for AI models, especially in complex fields such as healthcare and manufacturing. Meanwhile, biased data negatively affect the performance of AI models, and untested evaluation datasets can result in false positives or overestimates of model accuracy.
Neil Majithia   +3 more
wiley   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang   +12 more
wiley   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu   +14 more
wiley   +1 more source

AIE‐Active Cationic Tripyrrole Targeting Mitochondrial SDHAF1 for Acute Myeloid Leukemia Therapy

open access: yesAggregate, Volume 7, Issue 3, March 2026.
Cationic tripyrrole oligomers (Tri‐DPPy) selectively accumulate in mitochondria and suppress Complex II activity by binding to SDHAF1, thereby effectively eradicating AML cells both in vitro and in vivo. ABSTRACT Therapy‐resistant acute myeloid leukemia (AML) depends on mitochondrial oxidative phosphorylation (OXPHOS) to meet its energy demands, and ...
Wangxing Lin   +6 more
wiley   +1 more source

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