Results 41 to 50 of about 2,013 (228)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

A REVIEW OF ARABIC TEXT RECOGNITION DATASET

Asia-Pacific Journal of Information Technology and Multimedia, 2020
Building a robust Optical Character Recognition (OCR) system for languages, such as Arabic with cursive scripts, has always been challenging. These challenges increase if the text contains diacritics of different sizes for characters and words.
Idris Saleh Al-Sheikh, Masnizah Mohd, Lia Warlina   +2 more
doaj   +1 more source

Khmer printed character recognition using attention-based Seq2Seq network

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2022
This paper presents an end-to-end deep convolutional recurrent neural network solution for Khmer optical character recognition (OCR) task. The proposed solution uses a sequence-to-sequence (Seq2Seq) architecture with attention mechanism.
Rina Buoy, Nguonly Taing, Sovisal Chenda, Sokchea Kor   +3 more
doaj   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

A hybrid approach to Bangla handwritten OCR: combining YOLO and an advanced CNN

Discover Artificial Intelligence
Optical Character Recognition (OCR) plays a vital role in automating data entry from handwritten forms into digital systems. However, a significant gap exists in the research on OCR techniques tailored for handwritten texts in complex languages such as ...
Aye T. Maung, Sumaiya Salekin, Mohammad A. Haque   +2 more
doaj   +1 more source

PR2 model: An extended framework for Mongolian OCR pre-trained models with prompt tuning in Internet of Things

Alexandria Engineering Journal
This paper presents the PR2 model, designed to address optical character recognition (OCR) for Mongolian, a low-resource language, in complex backgrounds.
Siqintu Qi, Amuguleng Wang, Dahu Baiyila
doaj   +1 more source

Optimizing Statistical Character Recognition Using Evolutionary Strategies to Recognize Aircraft Tail Numbers

EURASIP Journal on Advances in Signal Processing, 2004
The design of statistical classification systems for optical character recognition (OCR) is a cumbersome task. This paper proposes a method using evolutionary strategies (ES) to evolve and upgrade the set of parameters in an OCR system.
Antonio Berlanga, Juan A. Besada, Jesús García Herrero, José M. Molina, Javier I. Portillo, José R. Casar   +5 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source