Results 41 to 50 of about 4,171,964 (283)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Design of high-performance millimeter wave and sub-millimeter wave quasi-optical isolators and circulators [PDF]

open access: yes, 2007
Faraday rotators using permanently magnetized ferrite materials are used to make quasi-optical isolators and circulators at millimeter wave and sub-millimeter wave frequencies that have far higher performance than their waveguide equivalents.
Goy, P   +10 more
core   +2 more sources

Lifetime Enhancement of a Circulated Cooling Perovskite Quantum Dots Colloidal Solution System for Laser Illuminations

open access: yesIEEE Access, 2019
Perovskite quantum dots (QDs) attracted a lot of attention recently due to their high light conversion efficiency, and high color purity. However, perovskite materials are sensitive to heat.
Zong-Tao Li   +7 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Carbon Quantum Dots Based Chemosensor Array for Monitoring Multiple Metal Ions

open access: yesMolecules, 2022
The simultaneous identification of multiple metal ions in water has attracted enormous research interest in the past few decades. We herein describe a novel method for multiple metal ion detection using a carbon quantum dots (CQDs)-based chemosensor ...
Tianlei Qin   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Organic polaritonic light-emitting diodes with high luminance and color purity toward laser displays

open access: yesLight: Science & Applications
Achieving high-luminescence organic light-emitting devices (OLEDs) with narrowband emission and high color purity is important in various optoelectronic fields.
Jianbo De   +10 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Development of Defect-Rich WO3-x/TiO2 Heterojunction Toward Dual-Functional Enhancement: Boosting SERS and Photocatalytic Performance

open access: yesNanomaterials
Semiconductors have emerged as promising candidates for surface-enhanced Raman scattering (SERS) applications due to their inexpensiveness and good chemical stability.
Xunfei He   +3 more
doaj   +1 more source

Cascaded forward Brillouin scattering to all Stokes orders

open access: yesNew Journal of Physics, 2017
Inelastic scattering processes such as Brillouin scattering can often function in cascaded regimes and this is likely to occur in certain integrated opto-acoustic devices.
C Wolff   +4 more
doaj   +1 more source

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