Results 31 to 40 of about 68,807 (272)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Brightest Black Holes

, 2002
I suggest that there are two classes of ultraluminous X-ray sources (ULXs), corresponding to super-Eddington mass inflow in two situations: (a) thermal-timescale mass transfer in high-mass X-ray binaries, and (b) long-lasting transient outbursts in low ...
A. R., , Abramowicz, Begelman, Dubus, Dubus, Ebisuzaki, Fabbiano, Finoguenov, Frank, Goad, Greiner, Jaroszynski, King, King, King, King, King, King, King, King, King, King★, , Koerding, Lasota, Madau, Makishima, Markoff, Miller, Mirabel, Piro, Podsiadlowski, Pringle, Revnivtsev, Ritter, Roberts, Sarazin, Shaviv, Shaviv, Sugiho, Watson   +39 more
core   +1 more source

An equatorial wind from the massive young stellar object S140 IRS 1 [PDF]

, 2006
The discovery of the second equatorial ionized stellar wind from a massive young stellar object is reported. High resolution radio continuum maps of S140 IRS 1 reveal a highly elongated source that is perpendicular to the larger scale bipolar molecular ...
Aspin C., Bunn J. C., Corcoran D., Drew J. E., Drew J. E., Gledhill T. M., Hofner P., Melvin G. Hoare, Minchin N. R., Minchin N. R., Oudmaijer R. D., Poetzel R., Schertl D., Sim S. A., Solf J., Tofani G., Wright A. E.   +16 more
core   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Enhancing ROP plus form diagnosis: An automatic blood vessel segmentation approach for newborn fundus images

Results in Engineering
Background: ROP Plus Form is an eye disease that can lead to blindness, and diagnosing it requires medical experts to manually examine the retinal condition. This task is challenging due to its subjective nature and poor image quality.
José Almeida, Jan Kubicek, Marek Penhaker, Martin Cerny, Martin Augustynek, Alice Varysova, Avinash Bansal, Juraj Timkovic   +7 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The design and development of a self-commutating stepper motor [PDF]

, 1979
The system discussed adopts a well established and space proven motor, the 'stepper-motor' and shows that with simple commutation techniques it can be operated as a brushless dc motor at high ...
Dalley, K. R.
core   +1 more source

The boundary layer of VW Hyi in quiescence [PDF]

, 2004
In this letter, we suggest that the missing boundary layer luminosity of dwarf novae in quiescence is released mainly in the ultraviolet (UV) as the second component commonly identified in the far ultraviolet (FUV) as the "accretion belt".
Belloni, E. M. Sion, Gill, Godon, Gänsicke, Hasenkopf, Kippenhahn, Kutter, Kutter, Long, Lynden-Bell, Mateo, Narayan, P. Godon, Pandel, Polidan, Popham, Pringle, Pringle, Schoembs, Shakura, Sion, Sion, Sion, Sion, Sion, van Amerongen, van der Woerd, Verbunt, Warner   +29 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source