Results 41 to 50 of about 2,277,534 (295)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optical Pipelined Multi‐bus Interconnection Network Intrinsic Topologies

ETRI Journal, 2017
Digital all‐optical parallel computing is an important research direction and spans conventional devices and convergent nano‐optics deployments. Optical bus‐based interconnects provide interesting aspects such as relative information communication speed ...
Brian Joseph d'Auriol
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Interconnection networks for parallel and distributed computing [PDF]

, 2008
Parallel computers are generally either shared-memory machines or distributed- memory machines. There are currently technological limitations on shared-memory architectures and so parallel computers utilizing a large number of processors tend tube ...
Xiang, Yonghong
core  

Multi-Node All-Optical Interconnect Network Routing for Data-Center Parallel Computers

IEEE Photonics Journal, 2019
A multi-node all-optical interconnect network-routing architecture scheme and implementation technology are designed to improve high-speed and large-capacity data transmission in data centers.
Shuailong Yang, Liu Yang, Fengguang Luo, Biyu You, Yao Ni, Danhui Chen   +5 more
doaj   +1 more source

Fault-Tolerant Resolvability of Swapped Optical Transpose Interconnection System

Journal of Mathematics, 2022
Interconnection systems in computer science and information technology are mainly represented by graphs. One such instance is of swapped network simulated by the optical transpose interconnection system (OTIS).
Iffat Fida Hussain, Sheeba Afridi, Ahmad Mahmood Qureshi, Gohar Ali, Usman Ali   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A Hybrid-Plasmonic-Waveguide-Based Polarization-Independent Directional Coupler

IEEE Access, 2020
In optical interconnection field, inconsistent coupling behaviors of TE and TM modes may cause abnormal operation. Therefore, it is very significant to implement a polarization-independent directional coupler.
Li Zhang, Can Pan, Dezheng Zeng, Yanzhao Yang, Yatao Yang, Junxian Ma   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source