Results 31 to 40 of about 4,554 (261)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On chip control and detection of complex SPP and waveguide modes based on plasmonic interconnect circuits

Nanophotonics
Optical interconnects, leveraging surface plasmon modes, are revolutionizing high-performance computing and AI, overcoming the limitations of electrical interconnects in speed, energy efficiency, and miniaturization.
Zhang Canran, Xu Yijing, Tao Hui, Wang Pan, Cui Yunkang, Wang Qilong   +5 more
doaj   +1 more source

Improved Power Budget of 112 Gb/s/$\lambda$ Intra-Datacentre Links Using a Split-Carrier Transmitter Architecture

IEEE Photonics Journal, 2019
A split-carrier transmitter is proposed to improve loss budget for short distance 100 G-per-wavelength intra-datacentre links. By applying a low-complexity hardware modification to the transmitter, the proposed architecture reduces transmitter ...
Thomas Gerard, Zhixin Liu, M. Sezer Erkilinc, Lidia Galdino, Polina Bayvel, Benn Thomsen, Domanic Lavery   +6 more
doaj   +1 more source

Exploring a Band-Edge Bragg Grating Modulator on a Hybrid Thin-Film Lithium Niobate Platform

IEEE Photonics Journal, 2021
In this work, we design, model, and characterize the Bragg grating modulator (BGM) on silicon-rich nitride and thin-film lithium niobate (SRN-TFLN) platform.
Xingrui Huang, Yang Liu, Huan Guan, Zhiguo Yu, Manqing Tan, Zhiyong Li   +5 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Polarization-Rotator-Free Polarization-Diversity 4 $\times$ 4 Si-Wire Optical Switch

IEEE Photonics Journal, 2016
We present a polarization-diversity 4 $\times$ 4 optical switch composed of silicon-wire waveguides. The proposed 4 $\times$ 4 switch does not require a polarization rotator, which enforces a modification in a standard complementary metal–oxide&#
K. Suzuki, K. Tanizawa, S.-H. Kim, S. Suda, G. Cong, K. Ikeda, S. Namiki, H. Kawashima   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source