Results 121 to 130 of about 28,505,010 (346)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Investigation of production routes for various radioisotopes and their excitation function studies significant to PET technology

Journal of Taibah University for Science
Excitation functions for the production route of light non-metallic radioisotopes 11C, 13N, 15O and 18F and metallic radioisotope 64Cu are evaluated using the statistical model code EMPIRE-3.2.
Milan Singh, Kuldeep Kholiya, D. P. Singh, Kailash Pandey   +3 more
doaj   +1 more source

Nonlinear optical components for all-optical probabilistic graphical model

Nature Communications, 2018
To circumvent the limitations of electronic computers, moving to hybrid optical-electronic or all-optical devices may be useful. Here, Babaeian et al. present an all-optical implementation of the probabilistic graphical model using nonlinear optics in ...
Masoud Babaeian, Pierre-A. Blanche, Robert A. Norwood, Tommi Kaplas, Patrick Keiffer, Yuri Svirko, Taylor G. Allen, Vincent W. Chen, San-Hui Chi, Joseph W. Perry, Seth R. Marder, Mark A. Neifeld, N. Peyghambarian   +12 more
doaj   +1 more source

Improved AWG Fourier optics model

Optics Express, 2004
In this paper we present an improved Fourier Optics model to calculate the transmission characteristics between any arbitrary pair of input/output ports (IOPs) of an Arrayed Waveguide Grating (AWG). In this model the input and output sections of the AWG are modeled using the same approximations, thus removing some reciprocity-related inconsistencies ...
I, Molina-Fernández, J, Wangüemert-Pérez   +1 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Optical excess of dim isolated neutron stars

, 2017
The optical excess in the spectra of dim isolated neutron stars (XDINs) is a significant fraction of their rotational energy loss-rate. This is strikingly different from the situation in isolated radio pulsars.
Alpar, M. Ali, Caliskan, Sirin, Ertan, Unal   +2 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Three-Dimension Calculation for the Scattering Problem for Non-Spherical Potential

Physics
The interaction of the 238U with a neutron is studied. Correct accounting for the non-spherical shape of the uranium nucleus is in focus. The optical potential is used as a model.
Pavel M. Krassovitskiy, Fedor M. Pen’kov   +1 more
doaj   +1 more source

An HCMT model of optical microring-resonators [PDF]

, 2010
Analytical modes of the bus and cavity cores are combined into a 2-D hybrid analytical / numerical coupled mode theory (HCMT) model of integrated optical ring-resonators. The variational technique generates 1-D FEM-discretized solutions for the amplitude
Hammer, Manfred
core   +2 more sources