Results 151 to 160 of about 44,823,850 (352)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Nonlinear optical components for all-optical probabilistic graphical model

Nature Communications, 2018
To circumvent the limitations of electronic computers, moving to hybrid optical-electronic or all-optical devices may be useful. Here, Babaeian et al. present an all-optical implementation of the probabilistic graphical model using nonlinear optics in ...
Masoud Babaeian, Pierre-A. Blanche, Robert A. Norwood, Tommi Kaplas, Patrick Keiffer, Yuri Svirko, Taylor G. Allen, Vincent W. Chen, San-Hui Chi, Joseph W. Perry, Seth R. Marder, Mark A. Neifeld, N. Peyghambarian   +12 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Three-Dimension Calculation for the Scattering Problem for Non-Spherical Potential

Physics
The interaction of the 238U with a neutron is studied. Correct accounting for the non-spherical shape of the uranium nucleus is in focus. The optical potential is used as a model.
Pavel M. Krassovitskiy, Fedor M. Pen’kov   +1 more
doaj   +1 more source

Development of a bio-optical model for the Barents Sea to quantitatively link glider and satellite observations. [PDF]

Philos Trans A Math Phys Eng Sci, 2020
Kostakis I, Röttgers R, Orkney A, Bouman HA, Porter M, Cottier F, Berge J, McKee D.   +7 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Fixed-rate-breaking All-optical OFDM system using time-domain hybrid PAM with sparse subcarrier multiplexing and power-loading for optical short-reach transmission

, 2020
All-optical TDHP-OFDM system with four-sparse-subcarrier-multiplexing and power-loading has been proposed for data-rate-adaptive transmission. 40-Gbit/s, 60-Gbit/s, and 80-Gbit/s can be selected by changing the ratio of PAM2 and PAM4, and all BERs ...
Kodama T., Wada N., Cincotti G., Maruta A.   +3 more
core   +1 more source

Using the Lens Paradox to Optimize an In Vivo MRI-Based Optical Model of the Aging Human Crystalline Lens. [PDF]

Transl Vis Sci Technol, 2020
Lie AL, Pan X, White TW, Donaldson PJ, Vaghefi E.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Systematic study of the propagation of uncertainties to transfer observables

Frontiers in Physics
A systematic study of parametric uncertainties in transfer reactions is performed using the recently developed uncertainty quantified global optical potential (KDUQ).
C. Hebborn, C. Hebborn, C. Hebborn, F. M. Nunes, F. M. Nunes   +4 more
doaj   +1 more source