Results 81 to 90 of about 1,807,617 (309)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Follow the BAT: Monitoring Swift BAT FoV for Prompt Optical Emission from Gamma-ray Bursts [PDF]

, 2011
We investigate the feasibility of implementing a system called 'Follow the BAT' that will coordinate ground-based robotic optical and near infrared (NIR) telescopes to monitor the Swift BAT field-of-view (FoV). The system will optimize the monitoring locations in the BAT FoV based on individual robotic telescopes' location, FoV, sensitivity and local ...
arxiv   +1 more source

Optical Performance Monitoring in Fiber-Optic Networks Enabled by Machine Learning Techniques

Optical Fiber Communications Conference and Exhibition, 2018
We review applications of machine learning (ML) in various aspects of optical communications including optical performance monitoring, fiber nonlinearity compensation, and software-defined networking.
F. Khan, Chao Lu, A. Lau
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

Optical Performance Monitoring Technology of IMDD System based on Deep Neural Network

Guangtongxin yanjiu, 2023
In advanced high-speed fiber optic communication systems, due to the introduction of dense wavelength division multiplexing technology, the signal spectral interval is getting narrower and narrower, and the traditional out-of-band Optical Signal-to-Noise
LIU Jun, LI Bo-zhong, CHENG Fang, LI Zi-fan, GUO Ying, SUN Yu-xiao, DENG Cun-xue, ZHANG Ru-yi, WANG Ying-xu   +8 more
doaj  

Separability of Histogram Based Features for Optical Performance Monitoring: An Investigation Using t-SNE Technique

IEEE Photonics Journal, 2019
In this paper, we study the separability of the commonly used features to monitor the performance of optical signal in coherent optical systems. Specifically, our study focuses on the histogram-based features; the asynchronous amplitude histogram (AAH ...
W. Saif, Tariq A. Alshawi, M. Esmail, A. Ragheb, S. Alshebeili   +4 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Machine Learning Techniques for Optical Performance Monitoring From Directly Detected PDM-QAM Signals

Journal of Lightwave Technology, 2017
Linear signal processing algorithms are effective in dealing with linear transmission channel and linear signal detection, whereas the nonlinear signal processing algorithms, from the machine learning community, are effective in dealing with nonlinear ...
Jakob Thrane, Jesper Wass, M. Piels, J. Diniz, R. Jones, D. Zibar   +5 more
semanticscholar   +1 more source