Results 41 to 50 of about 170,192 (312)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Functionalized Optical Microcavities for Sensing Applications

Nanomaterials
Functionalized optical microcavities constitute an emerging highly sensitive and highly selective sensing technology. By combining optical microcavities with novel materials, microcavity sensors offer exceptional precision, unlocking considerable ...
Evelyn Granizo, Pavel Samokhvalov, Igor Nabiev   +2 more
doaj   +1 more source

Fiber Taper-Based Mach–Zehnder Interferometer for Ethanol Concentration Measurement

Micromachines, 2019
We present a new type of fiber Mach−Zehnder interferometer based on a fiber taper and a pair of inner air bubbles for highly sensitive ethanol concentration measurement.
Changrui Liao, Feng Zhu, Peng Zhou, Ying Wang   +3 more
doaj   +1 more source

Online Gamma Radiation Monitoring Using Few-Mode Polymer CYTOP Fiber Bragg Gratings

Sensors, 2022
We investigated the gamma radiation response of fiber Bragg gratings (FBGs) inscribed in a few-mode polymer optical fiber. The fiber had a graded-index CYTOP core of 20 µm and XYLEX overclad of 250 µm in diameter.
Ivan Chapalo, Andrei Gusarov, Andreas Ioannou, Andreas Pospori, Karima Chah, Ying-Gang Nan, Kyriacos Kalli, Patrice Mégret   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers

Micromachines, 2020
The conventional methods for monitoring IgG levels suffer from some apparent problems such as long assay time, multistep processing, and high overall cost.
Bing Sun, Yiping Wang
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Global Shutter and Charge Binning With Quantum Dots Photodiode Arrays for NIR Imaging

IEEE Journal of the Electron Devices Society
New applications like depth measurements or multispectral imaging require to develop image sensors able to sense efficiently in the Near Infrared and Short-Wave Infrared where silicon is weakly sensitive.
Loic Baudoin, Arthur Arnaud, Sebastien Massenot, Pierre Magnan   +3 more
doaj   +1 more source