Results 31 to 40 of about 47,783 (291)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
IEEE AccessEmerging applications such as Artificial Intelligence (AI), the Internet of Things (IoT), and Big Data are significantly increasing data traffic within data center networks and high-performance computing (HPC) systems.
Mohammad Amin Mahdian +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Large-Scale and Simple-Configuration Optical Switch Enabled by Asymmetric-Port-Count Subswitches
IEEE Photonics Journal, 2016 We propose a novel optical switch architecture for intra-datacenter interconnection. The proposed switch consists of asymmetric-port-count delivery-and-coupling (DC) switches and wavelength-routing (WR) switches based on arrayed-waveguide gratings (AWGs).
Koh Ueda +4 more
doaj +1 more source
LIQUID CRYSTAL BASED OPTICAL SWITCHES [PDF]
Molecular Crystals and Liquid Crystals, 2004 Optical switches using two electro-optical effects in liquid crystals are proposed and investigated for incorporation in a switch matrix for optical networks. These two devices employ selective reflection in cholesteric layers and total reflection at the border between glass and nematic liquid crystal.
Semenova, Yuliya +3 more
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Nanomaterials, 2022 Fano resonances that feature strong field enhancement in the narrowband range have motivated extensive studies of light–matter interactions in plasmonic nanomaterials.
Xiaofeng Xu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
All-Optical Switching Improvement Using Photonic-Crystal Fano Structures
IEEE Photonics Journal, 2016 We investigate the intensity and phase response of optical switches based on a photonic crystal waveguide coupled to a nanocavity. In particular, we compare the performances of switches with traditional Lorentzian transmission spectrum to switches ...
Yi Yu +5 more
doaj +1 more source