Results 141 to 150 of about 2,534,041 (331)

Efficient characterization of red blood cell rheological properties using a multichannel microfluidic chip and optical tweezers

Materials Today Advances
The rheological properties of red blood cells (RBCs) are crucial for human health. Combining optical tweezers with microfluidics provides a non-contact, sensitive, and high-throughput method for studying RBC rheology.
Ying Liu, Hongtao Rao, Hongliang Zhang, Meng Wang, Yinglian Wu, Ying Wu, Caiqin Han, Changchun Yan, Le Zhang, Wei Chen, JingJing Wang   +10 more
doaj  

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Advanced Science, EarlyView.
A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod, Ryan N. Stack, Sarah E. Kubik, Stephanie A. Huang, Chloe P. Whitworth, Wen Y. Aw, Elizabeth L. Doherty, Sara M. Meehan, Prabir Roy‐Chaudhury, William J. Polacheck   +9 more
wiley   +1 more source

Instant Writing of Conductive Interface on MOF Single Crystal by Ultrafast Laser

Advanced Science, EarlyView.
Current device fabrication strategies lack capacity for tailoring ideal electrical interface in individual MOF single crystals. An ultrafast laser approach is developed that in situ constructs stable conductive interface on MOF single crystal scale while maintaining its crystalline integrity.
Dongsheng Huang, Shuailong Guo, Peng Chen, Yanan Liu, Zhenhua Wang, Ye Ding, Hao Li, Huijun Wu, Zhiyuan Ma, Haoqing Jiang, Lijun Yang, Hongxing Xu   +11 more
wiley   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Bacteria Optimize Tumble Bias to Strategically Navigate Surface Constraints

Advanced Science, EarlyView.
The study investigates how Escherichia coli optimizes tumble bias (TB) to navigate surface constraints effectively. Using single‐cell tracking and modeling, it reveals that bacterial surface residence time decreases with increasing TB, stabilizing near the wild‐type mean TB (≈0.25), where surface diffusivity peaks.
Antai Tao, Guangzhe Liu, Rongjing Zhang, Junhua Yuan   +3 more
wiley   +1 more source

Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers [PDF]

, 2002
Maneesh Arya, Bahman Anvari, Gabriel M. Romo, Miguel A. Crúz, Jing-fei Dong, Larry V. McIntire, Joel L. Moake, J. Faus Lopez   +7 more
openalex   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
wiley   +1 more source

Label-Free Continuous Cell Sorting Using Optofluidic Chip

Micromachines
In the field of biomedicine, efficiently and non-invasively isolating target cells has always been one of the core challenges. Optical fiber tweezers offer precise and non-invasive manipulation of cells within a medium and can be easily integrated with ...
Yingjie Zhang, Tao Zhang, Xinchun Zhang, Jingmeng Cheng, Sixiang Zhang   +4 more
doaj   +1 more source

Membrane Tether Formation from Outer Hair Cells with Optical Tweezers [PDF]

, 2002
Zhiwei Li, Bahman Anvari, Masayoshi Takashima, Peter Brecht, Jorge H. Torres, William E. Brownell   +5 more
openalex   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source