Results 141 to 150 of about 3,665,900 (304)

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

On a Method for Constructing Optimal Difference Formulas Using Discrete Operators with Variable Coefficients

Algorithms
This paper deals with the problem of constructing optimal difference formulas in the Hilbert space H2m0,1 through Sobolev’s method. Firstly, Sobolev’s method of construction of optimal difference formulas in the Hilbert space H2m0,1, which is based on ...
Kholmat Shadimetov, Shermamat Esanov
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

A Posteriori Error Estimators for Elliptic Equations with Discontinuous Coefficients

, 2002
We consider linear elliptic equations with discontinuous coefficients in two and three space dimensions with varying boundary conditions. The problem is discretized with linear finite elements. An adaptive procedure based on a posteriori error estimators
Petzoldt, Martin
core   +1 more source

Solvability of an optimal control problem in coefficients for ill-posed elliptic boundary-value problems

Electronic Journal of Differential Equations, 2014
We study an optimal control problem (OCP) associated to a linear elliptic equation $-\hbox{div}(A(x)\nabla y+C(x)\nabla y)=f$. The characteristic feature of this control object is the fact that the matrix $C(x)$ is skew-symmetric and belongs to $
Ciro D'Apice, Umberto De Maio, Peter I. Kogut, Rosanna Manzo   +3 more
doaj  

Optimizing the diffusion coefficient of overdamped Langevin dynamics

Mathematics of Computation
Overdamped Langevin dynamics are reversible stochastic differential equations which are commonly used to sample probability measures in high-dimensional spaces, such as the ones appearing in computational statistical physics and Bayesian inference. By varying the diffusion coefficient, there are in fact infinitely many overdamped Langevin dynamics ...
Lelièvre, Tony, Pavliotis, Grigorios A., Robin, Geneviève, Santet, Régis, Stoltz, Gabriel   +4 more
openaire   +3 more sources

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Sara Ho, Ziling Shen, Alexandria Lewis, Megha Patel, Anny Zheng, Gianna Proscino, Thaovy Ho, Jiangxia Wang, Marilyn Albert, Abhay Moghekar   +9 more
wiley   +1 more source

Optimal Control Problems in Coefficients for Degenerate Equations of Monotone Type: Shape Stability and Attainability Problems

, 2012
In this paper we study a Dirichlet optimal control problem for a nonlinear monotone equation with degenerate weight function and with the coefficients which we adopt as controls in L∞(Ω).
OL’GA P. KOGUT, Ciro D'Apice, U. DE MAIO, Ol'ga P. Kogut, DE MAIO, UMBERTO, C. D’APICE, Umberto De Maio, D'APICE, Ciro, O. KOGUT   +8 more
core   +1 more source

LOCC convertibility of entangled states in infinite-dimensional systems

New Journal of Physics
We advance on the conversion of bipartite quantum states via local operations and classical communication (LOCC) for infinite-dimensional systems. We introduce δ -LOCC convertibility based on the observation that any pure state can be approximated by a ...
César Massri, Guido Bellomo, Hector Freytes, Roberto Giuntini, Giuseppe Sergioli, Gustavo M Bosyk   +5 more
doaj   +1 more source