Results 51 to 60 of about 356,985 (308)

Optimal time-based and cost-based contracts in construction projects under asymmetric information

Journal of Civil Engineering and Management
A project owner (principal) delegates a project to a contractor (agent). Because the contractor has construction experience, he has private information about the project’s expected completion time.
Guanqun Shi, Jingru Tong, Zhiyuan Chen, Yichen Wang   +3 more
doaj   +1 more source

Optimization model for multi-products multi-periods multi-suppliers raw-material selection and composition, and order quantity problem with one-year minimum order quantity contract

MethodsX, 2023
This paper concerns the optimization model for a multi-product multi-period raw-material selection and composition, and order quantity problem faced by a beverage company.
Mohammad Rizka Fadhli, Saladin Uttunggadewa, Rieske Hadianti, Sri Redjeki Pudjaprasetya   +3 more
doaj   +1 more source

Optimal Contracting and the Organization of Knowledge [PDF]

The Review of Economic Studies, 2014
We study contractual arrangements that support an efficient use of time in a knowledge-intensive economy in which agents endogenously specialize in either production or consulting. The resulting market for advice is plagued by informational problems, since both the difficulty of the questions posed to consultants and the knowledge of those consultants ...
William Fuchs, Luis Garicano, Luis Rayo
openaire   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Information Acquisition and Its Incentives in an E-Commerce Supply Chain under the Offline Showroom Model

Journal of Theoretical and Applied Electronic Commerce Research, 2021
Recently, the showroom model has developed fast for allowing consumers to evaluate a product offline and then buy it online. This paper aims at exploring the optimal information acquisition strategy and its incentive contracts in an e-commerce supply ...
Mengli Li, Xumei Zhang
doaj   +1 more source

Monotonicity of second-best optimal contracts [PDF]

, 1987
Includes bibliographical references (p. 17)
Monahan, George E., Vemuri, Vijay K.
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Research on the improvement mechanism of value-based healthcare objectives in pharmaceutical group procurement

Heliyon
Focusing on the research scenario that integrates value-based healthcare objectives with the pharmaceutical group purchasing model, this study delineates value-based healthcare objectives in pharmaceutical group purchasing from three perspectives: drug ...
Zhao Li, Wanzhi Shen, Tao Zhang
doaj   +1 more source

Optimal Pricing and Ordering Strategies with a Flexible Return Strategy under Uncertainty

Mathematics, 2021
To coordinate the supply chain risk caused by demand uncertainty, this paper proposed a flexible return strategy under demand uncertainty, in which the retailer can choose return quantity independently by put option after the selling season, while the ...
Pan Guo, Yanlin Jia, Junwei Gan, Xiaofeng Li   +3 more
doaj   +1 more source